Table 1 WHO clinical staging of HIV disease
Stage | Symptoms |
|---|---|
Clinical Stage 1 | Asymptomatic Persistent generalized lymphadenopathy |
Clinical Stage 2 | Moderate unexplained weight loss (< 10% of presumed or measured body weight) Recurrent respiratory tract infections (sinusitis, tonsillitis, otitis media, pharyngitis) Herpes zoster (in the last five years) Angular cheilitis Recurrent oral ulceration Popular pruritic eruption Fungal nail infections Seborrheic dermatitis |
Clinical Stage 3 | Unexplained severe weight loss (> 10% of presumed or measured body weight) Unexplained chronic diarrhea for longer than one month Unexplained persistent fever (intermittent or constant for longer than one month) Persistent oral candidiasis (now or in the last two years) Oral hairy leukoplakia Pulmonary tuberculosis (now or in the last two years) Severe bacterial infections (such as pneumonia, empyema, pyomyositis, bone or joint infection, meningitis, bacteremia) Acute necrotizing ulcerative stomatitis, gingivitis, or periodontitis Unexplained anemia (< 8 g/dl), neutropenia (< 0.5 × 109/L) and/or chronic thrombocytopenia (< 50 × 109/L) |
Clinical Stage 4 | HIV wasting syndrome Pneumocystis (jirovecii) pneumonia Recurrent severe bacterial pneumonia Chronic herpes simplex infection (orolabial, genital, or anorectal of more than one month in duration or visceral at any site) Esophageal candidiasis (or candidiasis of the trachea, bronchi, or lungs) Extrapulmonary tuberculosis Kaposi sarcoma Cytomegalovirus infection (retinitis or infection of other organs) Central nervous system toxoplasmosis HIV encephalopathy Extrapulmonary cryptococcosis, including meningitis Disseminated nontuberculous mycobacterial infection Progressive multifocal leukoencephalopathy (PML) Chronic cryptosporidiosis Chronic isosporiasis Disseminated mycosis (extrapulmonary histoplasmosis, coccidioidomycosis) Lymphoma (cerebral or B-cell non-Hodgkin) Symptomatic HIV-associated nephropathy or cardiomyopathy Recurrent septicemia (including nontyphoidal Salmonella) Invasive cervical carcinoma Atypical disseminated leishmaniasis |