Table 3 Analysis of the associations between AKI and vancomycin trough concentration

vancomycin trough concentration

 < 0.001

1.040

1.029–1.052

0.001

1.025

1.010–1.040

Age

0.764

1.002

0.991–1.013

-

-

-

Myocardial infarction

 < 0.001

3.614

2.414–5.140

0.892

1.043

0.566–1.924

Congestive heart failure

 < 0.001

5.712

4.157–7.849

0.003

2.254

1.323–3.840

Hypertension

 < 0.001

1.580

1.337–1.868

0.143

1.191

0.943–1.506

Diabetes

0.064

1.179

0.990–1.404

0.061

1.264

0.990–1.614

Renal disease

 < 0.001

2.097

1.662–2.644

0.710

1.069

0.754–1.515

Malignant cancer

0.017

1.284

1.045–1.577

0.972

1.202

0.940–1.536

Liver disease

 < 0.001

0.779

0.634–0.957

0.203

1.526

0.796–2.924

White blood cell

0.549

1.003

0.992–1.015

-

-

-

Hemoglobin

0.001

0.914

0.866–0.966

0.916

0.996

0.923–1.085

Platelet

0.011

1.001

1.000–1.002

 < 0.001

1.003

1.002–1.005

Bilirubin

0.001

1.138

1.056–1.226

0.672

1.018

0.937–1.058

Albumin

 < 0.001

2.166

1.814–2.585

 < 0.001

1.560

1.256–1.887

Creatinine

 < 0.001

1.851

1.620–2.115

 < 0.001

1.597

1.308–1.849

Other nephrotoxic medications

 < 0.001

6.482

4.736–8.873

 < 0.001

3.017

1.964–4.635

GCS

 < 0.001

0.890

0.877–0.903

0.011

0.970

0.947–0.993

SOFA

 < 0.001

1.155

1.130–1.180

 < 0.001

1.424

1.080–1.209

Shock

 < 0.001

2.266

1.898–2.705

0.007

1.025

1.010–1.040