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Table 5 Rate of first complication at 3-, 6- and 12-months, overall and stratified by rCDIs

From: Epidemiological and clinical burden of Clostridioides difficile infections and recurrences between 2015 − 2019: the RECUR Germany study

 

Months (M) of follow-up

CDI patients

Patients without rCDI

(0 rCDI)

Patients with 1 rCDI

Patients with 2 rCDI

Patients with ≥ 3 rCDI

Patients with ≥ 1 rCDI

Number of patients

 

9,977

8,175

1,356

312

134

1,802

Any complication

3 M

838 (8.40%)

636 (7.78%)

148 (10.91%)

34 (10.90%)

20 (14.93%)

202 (11.21%)

6 M

1,032 (10.34%)

791 (9.68%)

174 (12.83%)

39 (12.50%)

28 (20.90%)

241 (13.37%)

12 M

1,240 (12.43%)

966 (11.82%)

200 (14.75%)

43 (13.78%)

31 (23.13%)

274 (15.21%)

Colonic perforation

3 M

9 (0.09%)

6 (0.07%)

3 (0.22%)

0 (0.00%)

0 (0.00%)

3 (0.17%)

6 M

15 (0.15%)

11 (0.13%)

4 (0.29%)

0 (0.00%)

0 (0.00%)

4 (0.22%)

12 M

19 (0.19%)

14 (0.17%)

5 (0.37%)

0 (0.00%)

0 (0.00%)

5 (0.28%)

Colectomy

3 M

197 (1.97%)

151 (1.85%)

36 (2.65%)

7 (2.24%)

3 (2.24%)

46 (2.55%)

6 M

247 (2.48%)

192 (2.35%)

43 (3.17%)

7 (2.24%)

5 (3.73%)

55 (3.05%)

12 M

319 (3.20%)

258 (3.16%)

47 (3.47%)

8 (2.56%)

6 (4.48%)

61 (3.39%)

Loop ileostomy

3 M

21 (0.21%)

18 (0.22%)

3 (0.22%)

0 (0.00%)

0 (0.00%)

3 (0.17%)

6 M

31 (0.31%)

26 (0.32%)

4 (0.29%)

0 (0.00%)

1 (0.75%)

5 (0.28%)

12 M

40 (0.40%)

33 (0.40%)

6 (0.44%)

0 (0.00%)

1 (0.75%)

7 (0.39%)

Toxic megacolon

3 M

15 (0.15%)

10 (0.12%)

4 (0.29%)

1 (0.32%)

0 (0.00%)

5 (0.28%)

6 M

15 (0.15%)

10 (0.12%)

4 (0.29%)

1 (0.32%)

0 (0.00%)

5 (0.28%)

12 M

17 (0.17%)

12 (0.15%)

4 (0.29%)

1 (0.32%)

0 (0.00%)

5 (0.28%)

Ulcerative colitis

3 M

83 (0.83%)

58 (0.71%)

21 (1.55%)

2 (0.64%)

2 (1.49%)

25 (1.39%)

6 M

95 (0.95%)

68 (0.83%)

22 (1.62%)

2 (0.64%)

3 (2.24%)

27 (1.50%)

12 M

113 (1.13%)

84 (1.03%)

24 (1.77%)

2 (0.64%)

3 (2.24%)

29 (1.61%)

Peritonitis

3 M

63 (0.63%)

52 (0.64%)

7 (0.52%)

1 (0.32%)

3 (2.24%)

11 (0.61%)

6 M

81 (0.81%)

66 (0.81%)

10 (0.74%)

1 (0.32%)

4 (2.99%)

15 (0.83%)

12 M

93 (0.93%)

76 (0.93%)

12 (0.88%)

1 (0.32%)

4 (2.99%)

17 (0.94%)

Sepsis

3 M

497 (4.98%)

373 (4.56%)

86 (6.34%)

23 (7.37%)

15 (11.19%)

124 (6.88%)

6 M

621 (6.22%)

471 (5.76%)

102 (7.52%)

29 (9.29%)

19 (14.18%)

150 (8.32%)

12 M

755 (7.57%)

577 (7.06%)

123 (9.07%)

32 (10.26%)

23 (17.16%)

178 (9.88%)

  1. CDI: C. difficile infection; rCDI: Recurrent C. difficile infection
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