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Table 1 Baseline characteristics of the discovery and validation cohorts of LB patients and controls

From: Genome-wide analyses in Lyme borreliosis: identification of a genetic variant associated with disease susceptibility and its immunological implications

Characteristic

Discovery

Validation

LB patients (n = 506)

Controls (n = 313)

LB patients (n = 557)

Controls (n = 441)

Male sex—no (%)

197 (38.9%)

141 (43.3%)

241 (43.3%)

211 (43.1%)

Age (years)

 median [min, max]

54 [19, 82]

23 [18, 71]

56 [19, 87]

23 [18, 75]

 mean (SD)

53.1 (13.3)

25.9 (10.6)

53.9 (11.8)

28.1 (13.5)

LB manifestation

 EM

465 (91.9%)

NA

556 (99.8%)

NA

 Disseminated LB

41 (8.1%)

1 (0.2%)

 ACA

18

1

 LNB

10

NA

Lyme arthritis

12

NA

Othera

1

NA

  1. The discovery cohort was compared to the 300BCG cohort, the validation cohort was compared to the 500FG cohort. All but one patients with a disseminated LB manifestation were included in the discovery cohort, although numbers were few
  2. Abbreviations: ACA acrodermatitis chronic atrophicans, EM erythema migrans, LB Lyme borreliosis, LNB Lyme neuroborreliosis
  3. aCategory ‘other’: early (sub)acute symptoms without erythema migrans