Fig. 6
LB susceptibility variants were associated with cytokine and antibody production. A A suggestive hit (p < 1.0–4) was observed for the missense variant rs2232950 and for rs4110197 after meta-analyzing the discovery and validation cohort. B Boxplots showing the relevance of LB susceptibility variant rs4110197 for baseline cytokine production in our physician-confirmed LB patients. C Boxplots showing the relevance of LB susceptibility variant rs4110197 for baseline antibody production in our physician-confirmed LB patients. D Association between rs1061632 genotypes and baseline B. burgdorferi s.l. antibody indexes (C6 IgM/IgG ELISA) in our physician-confirmed LB patients, p = 0.01 age, sex, batch, and institute corrected (linear model). E Association between rs1061632 genotypes and IL-10 production upon stimulation of whole blood samples with B. burgdorferi s.l. mix (MOI 10) at baseline in our physician-confirmed LB patients, p = 0.04 age, sex, batch, and institute corrected (linear model). F Negative Pearson correlation between B. burgdorferi s.l. antibody indexes (C6 IgM/IgG ELISA) and IL-10 production upon stimulation of PBMCs with B. burgdorferi s.l. 105/ml in our physician-confirmed LB patients at baseline