Table 1 Characteristics of participants with difficult-to-treat HIV, compared with non-difficult (N = 8531)
From: Difficult-to-treat HIV in Sweden: a cross-sectional study
Non-difficult-to-treat HIV | Difficult-to-treat HIV n=799 (9%) | |||||
|---|---|---|---|---|---|---|
Advanced resistance | 4DR | Salvage therapy | Recent virologic failure | ≥2 switches following failure | ||
n=7732 (91%) | n=188 (2%) | n=51 (1%) | n=141 (2%) | n=59 (1%) | n=519 (6%) | |
Assigned sex at birth | ||||||
Man | 4698 (61%) | 121 (64%) | 34 (67%) | 85 (60%) | 26 (44%) | 268 (52%) |
Woman | 3014 (39%) | 67 (36%) | 17 (33%) | 56 (40%) | 33 (56%) | 251 (48%) |
Missing | 20 (0%) | 0 | 0 | 0 | 0 | 0 |
Current age [year] | 51 (42-59) | 59 (51-64) | 57 (49-61) | 58 (50-65) | 49 (40-57) | 52 (43-59) |
Missing | 4 (0%) | 0 | 0 | 0 | 0 | 0 |
Current age < 18 yearsa | 89 (1%) | 12 (2%) | ||||
Year of first positive HIV test | 2009 (2002-2015) | 1993 (1990-2003) | 1999 (1993-2008) | 1996 (1992-2007) | 2005 (1998-2010) | 2004 (1997-2010) |
Missing | 140 (2%) | 1 (1%) | 0 | 0 | 1 (2%) | 2 (0%) |
HIV diagnosis before January 1, 1995 | 840 (11%) | 103 (55%) | 15 (29%) | 59 (42%) | 10 (17%) | 90 (17%) |
First CD4 count [cells/µL] | 370 (200-570) | 295 (140-490) | 260 (130-490) | 230 (140-440) | 330 (200-560) | 330 (175-520) |
Nadir CD4 count [cells/µL] | 246 (138-390) | 100 (30-190) | 130 (40-260) | 100 (50-220) | 130 (30-230) | 160 (70-260) |
Missing | 29 (0%) | 0 | 0 | 0 | 0 | 0 |
First HIV RNA [log10 copies/mL] | 4.4 (2.8-5.1) | 4.8 (3.7-5.2) | 4.8 (3.6-5.4) | 4.9 (3.7-5.6) | 4.5 (3.3-5.1) | 4.7 (3.8-5.3) |
Missing | 12 (0%) | 0 | 0 | 0 | 0 | 0 |
HIV risk groupa | ||||||
Heterosexual | 3913 (51%) | 430 (54%) | ||||
MSM | 2474 (32%) | 227 (28%) | ||||
IDU | 317 (4%) | 31 (4%) | ||||
Other | 905 (12%) | 108 (14%) | ||||
Missing | 123 (2%) | 3 (0%) | ||||
Born in Sweden | 2567 (33%) | 78 (41%) | 20 (39%) | 58 (41%) | 14 (24%) | 133 (26%) |
Country of birth missing | 90 (1%) | 1 (1%) | 0 | 1 (1%) | 0 | 1 (0%) |
Current ART regimen | ||||||
Includes NNRTI | 1741 (23%) | 47 (25%) | 11 (22%) | 41 (29%) | 8 (14%) | 59 (11%) |
Includes PI | 597 (8%) | 104 (55%) | 41 (80%) | 102 (72%) | 13 (22%) | 110 (21%) |
Includes INSTI | 5441 (70%) | 160 (85%) | 43 (84%) | 94 (67%) | 42 (71%) | 421 (81%) |
Includes PI + INSTI | 68 (1%) | 83 (44%) | 34 (67%) | 63 (45%) | 0 | 49 (9%) |
Has ≥1 resistance test | 4999 (65%) | 188 (100%) | 45 (88%) | 117 (83%) | 56 (95%) | 474 (91%) |
Number of missed doses during the last weeka (% among those who completed the questionnaire) | ||||||
0 | 3248 (88%) | 309 (82%) | ||||
1-2 | 382 (10%) | 54 (14%) | ||||
≥ 3 | 47 (1%) | 14 (4%) | ||||
No completed adherence questionnaire during the last 24 months | 4055 (52%) | 422 (53%) | ||||