Comparing the efficacy of fluconazole and cryotherapy Versus cryotherapy alone on treating cutaneous leishmaniasis: a triple-blind randomized clinical trial

Table 2 Trend and comparison of the mean (± SD) surface area of the lesion in two arms during the course of treatment

Arms	Week
Arms	1	2	3	4	5	6	Post-treatment	P ¹
Cryotherapy and fluconazole	14.83 ± 10.76	16.64 ± 10.86	15.51 ± 11.34	15.11 ± 11.80	11.68 ± 9.31	7.57 ± 7.66	4.27 ± 5.84	< 0.001
Cryotherapy and placebo	12.07 ± 8.92	14.84 ± 11.95	14.72 ± 10.56	14.73 ± 11.39	13.73 ± 13.15	9.35 ± 9.02	6.23 ± 8.62	< 0.001
P ²	0.164	0.433	0.721	0.870	0.371	0.291	0.188	0.133 ³
Mean difference with baseline, cm² Value 95% confidence interval Standard error P ⁴	-0.076 -1.019, 0.867 0.475 0.874	2.263 0.631, 3.895 0.822 0.007	1.645 0.108, 3.183 0.775 0.036	1.454 -0.195, 3.104 0.831 0.083	-0.781 -3.028, 1.466 1.132 0.492	-5.066 -7.238, -2.894 1.094 < 0.001	-8.302 -10.852, -5.751 1.285 < 0.001	-

¹ Repeated Measures Greenhouse-Geisser to assess the trend in the outcome for each arm
² Independent sample T-test to compare two arms in each time point
³ GLM to compare the arms for the trend in the outcome
⁴ Independent sample T-test to compare with baseline

ISSN: 1471-2334