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Table 5 Changes in laboratory parameters after taking DTG-based ART

From: Efficacy, safety, and tolerability of dolutegravir-based ART regimen in Durban, South Africa: a cohort study

Variable

Baseline

Frequency

(Proportion %)

After DTG-based ART

Frequency

(Proportion %)

T-test (p)

Haemoglobin (n = 204)

   

Normal (12 − 15 g/dl)

Low (< 12 g/dl)

Mean

156 (76.5)

48 (23.5)

12.96 ± 1.49

156 (76.5)

48 (23.5)

12.92 ± 1.45

0.555

Cholesterol (n = 169)

   

Normal (< 5 mmol/L)

Elevated (≥ 5 mmol/L)

Mean

121 (71.6)

48 (28.4)

4.5 ± 0.96

145 (85.8)

24 (14.2)

4.2 ± 1.02

< 0.001

Alanine transaminase (n = 197)

   

Normal (7 − 35 U/L)

Elevated (> 35 U/L)

Mean

162 (82.2)

35 (17.8)

27.28 ± 14.69

173 (87.8)

24 (12.2)

25.33 ± 16.76

0.129

Creatinine (n = 383)

   

Normal (49 − 90 µmol/L)

Elevated (> 90 µmol/L)

Low (< 49 µmol/L)

Mean

320 (85.6)

40 (10.4)

23 (6.0)

71.73 ± 16.73

254 (66.3)

121 (31.6)

8 (2.1)

84.13 ± 19.29

< 0.001