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Table 3 Study outcomes according to surgical prophylaxis exposure

From: Gram-negative bacterial colonizations before bilateral lung transplant. The impact of ‘targeted’ versus ‘standard’ surgical prophylaxis

 

Overall

N = 46 (100)

Standard prophylaxis

N = 24 (52)

Targeted prophylaxis

N = 22 (48)

p-value

Primary outcomes

30 (65)

14 (58)

16 (73)

0.364

Secondary outcomes

    

 Infections by ESBL/MDR GN bacteria, n (%)

15 (33)

4 (17)h

11 (50)h

0.027

 Colonizations by ESBL/MDR GN bacteria, n (%)

15 (33)

10 (42)

5 (23)

0.212

Other outcomes

    

 Infection by MS GN bacteria, n (%)

2(4)

1(4)

2(5)

0.999

 Infection by GP bacteria, n (%)

6 (13)

2 (8)

4 (18)l

0.405

 Invasive mechanical ventilation, hours

24 [20–59]

24 [19–64]

24 [20–59]

0.125

 Re-tracheal intubation and/or tracheostomy, n (%)

10 (22)

2 (8)

8 (36)

0.032

 Anastomotic complications, n (%)

4 (9)

2 (8)

2 (9)

0.999

 30-day acute rejectiong, n (%)

11 (24)

8 (33)

3 (14)

0.171

 ICU LOS, days

7 [5–17]

6 [3–14]

8 [6–23]

0.002

 Hospital LOS, days

33 [30–45]

33 [30–38]

35 [31–50]

0.039

 Hospital mortality, n (%)

3 (7)

0 (0)

3 (14)

0.101

 ECMO post-surgery, n (%)

5 (11)

3 (13)

2 (9)

0.999

 PGD at 72 h

1 [0–2]

1 [0–1]

1 [0–2]

0.286

 Immunosuppressive therapy (cyclosporine (ref))m

30 (65)

13 (54)

17 (77)

0.129

 Renal replacement therapy, n (%))

6 (13)

2 (8)

4 (19)

0.405

  1. *Data are expressed as number and (percentage) or median and [interquartile range]. h: One patient treated with ‘standard’ prophylaxis and one patient with ‘targeted’ therapy, defined as ‘infected’ by MDR GN bacteria, had also a secondary colonization by different MDR GN bacteria; i: one recipient, infected by a MS GN bacteria, was also colonized by a MDR GN bacteria. l: one patients was colonized by postoperative MDR GN bacteria. g: rejection is defined according to International Society for heart and lung transplantation (ISHLT) criteria (i.e., A3-A4 and/or B2 grade at biopsy) [38]. m: The other LT recipients were treated with tacrolimus. Abbreviations: MDR, multidrug-resistant; MS, multisensitive; ICU, intensive care unit; LOS, length of stay; H, hospital; ICU, intensive care unit; ECMO, extracorporeal membrane oxygenation; PGD, primary graft dysfunction; n, number