Overall N = 46 (100) | Standard prophylaxis N = 24 (52) | Targeted prophylaxis N = 22 (48) | p-value | |
---|---|---|---|---|
Primary outcomes | 30 (65) | 14 (58) | 16 (73) | 0.364 |
Secondary outcomes | ||||
Infections by ESBL/MDR GN bacteria, n (%) | 15 (33) | 4 (17)h | 11 (50)h | 0.027 |
Colonizations by ESBL/MDR GN bacteria, n (%) | 15 (33) | 10 (42) | 5 (23) | 0.212 |
Other outcomes | ||||
Infection by MS GN bacteria, n (%) | 2(4) | 1(4) | 2(5) | 0.999 |
Infection by GP bacteria, n (%) | 6 (13) | 2 (8) | 4 (18)l | 0.405 |
Invasive mechanical ventilation, hours | 24 [20–59] | 24 [19–64] | 24 [20–59] | 0.125 |
Re-tracheal intubation and/or tracheostomy, n (%) | 10 (22) | 2 (8) | 8 (36) | 0.032 |
Anastomotic complications, n (%) | 4 (9) | 2 (8) | 2 (9) | 0.999 |
30-day acute rejectiong, n (%) | 11 (24) | 8 (33) | 3 (14) | 0.171 |
ICU LOS, days | 7 [5–17] | 6 [3–14] | 8 [6–23] | 0.002 |
Hospital LOS, days | 33 [30–45] | 33 [30–38] | 35 [31–50] | 0.039 |
Hospital mortality, n (%) | 3 (7) | 0 (0) | 3 (14) | 0.101 |
ECMO post-surgery, n (%) | 5 (11) | 3 (13) | 2 (9) | 0.999 |
PGD at 72 h | 1 [0–2] | 1 [0–1] | 1 [0–2] | 0.286 |
Immunosuppressive therapy (cyclosporine (ref))m | 30 (65) | 13 (54) | 17 (77) | 0.129 |
Renal replacement therapy, n (%)) | 6 (13) | 2 (8) | 4 (19) | 0.405 |