Gram-negative bacterial colonizations before bilateral lung transplant. The impact of ‘targeted’ versus ‘standard’ surgical prophylaxis

Table 1 Baseline patient characteristics according to surgical prophylaxis exposure

	Overall N = 46 (100)	Standard prophylaxis N = 24 (52)	Targeted prophylaxis N = 22 (48)	p-value
Baseline characteristics
Age, years	43 [33–52]	43 [35–50]	43 [31–55]	0.836
Male gender, n (%)	24 (52)	16 (67)	8 (36)	0.075
BMI, kg/m²	21 [18–24]	21 [19–24]	20 [18–24]	0.812
Corticosteroids, n (%)	23 (50)	11 (46)	12 (55)	0.768
O₂ therapy, n (%)	38 (83)	21 (88)	17 (77)	0.451
Diabetes, n (%)	11 (24)	6 (25)	5 (23)	0.999
LAS	35 [34–39]	35 [34–39]	35 [33–39]	0.562
Oto score	3 [1–5]	3 [1–5]	2 [2–6]	0.827
Underlying diseases
Septic^a, n (%)	30 (65)	15 (63)	15 (68)	0.763
Interstitial^b, n (%)	7 (15)	4 (17)	3 (14)	0.999
Obstructive^c, n (%)	8 (17)	4 (17)	4 (18)	0.999
Others^d, n (%)	1 (2)	1 (4)	0 (0)	-
Previous colonization
Recipient-related MS GN bacteria	24 (52)	13 (58)	9 (45)	0.395
Recipient-related MDR GN bacteria	22 (48)	11 (42)	13 (55)	0.395
Donor-related GN bacteria^e	13 (28)	8 (33)	5 (23)	0.521
Recipient-related viral colonization	2 (4)	0 (0)	2 (9)	0.476

Data are expressed as number and (percentage) or median and [interquartile range]. ^aSeptic: cystic fibrosis, bronchiectasis; ^bInterstitial: idiopathic pulmonary fibrosis, allergic extrinsic alveolitis, non-specific interstitial pneumonia, fibrosing emphysema, lymphocytic interstitial pneumonia, respiratory bronchiolitis interstitial lung; ^cObstructive: chronic obstructive pulmonary disease; ^dOthers: idiopathic pulmonary hypertension, veno-occlusive disease, connective tissue disease, α1-anti-trypsin deficiency, lymphangioleiomyomatosis, histiocytosis, sarcoidosis, graft versus host disease. Abbreviations: BMI, body mass index; n, number; O2, oxygen; LAS, lung allocation score; MS, multisensitive; GN, Gram-negative; MDR, multidrug-resistant; LT, lung transplant;

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