Table 6 Causal effect of H. pylori infection on osteoporosis using genetic variant randomization in different MR methods
From: H. pylori infection and osteoporosis: a large-scale observational and mendelian randomization study
Exposure | Outcome | Method | No. of SNP | OR (95% CI) | 95% CI | P |
|---|---|---|---|---|---|---|
H. pylori infection | Osteoporosis | IVW | 12 | 1.0017 | 1.0002–1.0033 | 0.0217 |
|  |  | MR Egger | 12 | 1.0041 | 1.0002–1.0081 | 0.0631 |
|  |  | Weighted median | 12 | 1.0014 | 0.9993–1.0035 | 0.1746 |
|  |  | Simple mode | 12 | 1.0015 | 0.9981–1.0049 | 0.4066 |
|  |  | Weighted mode | 12 | 1.0014 | 0.9981–1.0047 | 0.4238 |
MR Egger: Cochran’s Q = 9.144, P = 0.518 |  |  |  |  |  |  |
IVW: Cochran’s Q = 10.833, P = 0.457 |  |  |  |  |  |  |
MR-Egger intercept=−0.0005, P = 0.2229 |  |  |  |  |  |  |
MR-PRESSO global test,P = 0.2229 |  |  |  |  |  |  |