Diagnostic accuracy of procalcitonin in adult non-neutropenic cancer patients with suspected infection: a systematic review and meta-analysis

Table 3 Summary of diagnostic accuracy of procalcitonin and C-reactive protein in detecting infection

Author, year	Infection/control (n)	Procalcitonin				C-reactive protein
Author, year	Infection/control (n)	Sensitivity	Specificity	AUC	Cutoff^† (mg/L)	Sensitivity	Specificity	AUC	Cutoff (mg/L)
Vassallo et al. 2021	87/44	0.75	0.55	–	0.52	–	–	–	–
Ding et al. 2020	311/277	0.80	0.80	0.87	0.105	0.86	0.71	0.86	12.2
Blouin et al. 2020	332/1699	0.58	0.74	0.71	1.695	–	–	–	–
Yang et al. 2019	18/323	0.61	0.75	0.76	0.5	0.67	0.74	0.76	100
Zhao et al. 2018	21/26	0.76	0.89	0.84	0.44	–	–	–	–
Penel et al. 2001	43/19	0.37	0.95	–	1	–	–	–	–
Kallio et al. 2000	56/10	0.29	0.80	0.61	0.5	0.39	0.70	0.42	140

AUC: Area under the curve; −: Not available
^†Yang et al. and Kallio et al. employed predefined cutoffs, whereas Ding et al. and Blouin et al. determined their cutoffs using Youden’s index. Vassallo et al., Penel et al., and Zhao et al. utilized optimal cutoffs, although without a precise definition

ISSN: 1471-2334