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Table 5 Histopathological characteristics of hrHPV Positives EAC and SCC

From: The distribution of hrHPV genotypes among cervical cancer cases diagnosed across Ghana: a cross-sectional study

 

Silva pattern of stromal invasion (for HPV A EAC only)

Tumour grading (Total score (TB + NS)) for SCC

Tumour TILS

Pattern B

Pattern C

Cannot be determined

Total

p-value

Well-differentiated (G1)

Moderately differentiated (G2)

Poorly differentiated (G3)

Total

p-value

Low (0–10%)

Intermediate (10–50%)

High (50–90%)

Total

p-value

HPV 16

1 (25%)

2 (9.5%)

0 (0%)

3 (11.5%)

0.630

7 (22.6%)

11 (18.3%)

11 (11.5%)

29 (15.5%)

0.253

23 (14.6%)

7 (16.3%)

2 (16.7%)

32 (15%)

0.949

HPV31

0 (0%)

1 (4.8%)

0 (0%)

1 (3.8%)

0.884

1 (3.2%)

3 (5%)

2 (2.1%)

6 (3.2%)

0.603

4 (2.5%)

3 (7%)

0 (0%)

7 (3.3%)

0.282

HPV39

0 (0%)

0 (0%)

0 (0%)

0 (0%)

–

0 (0%)

2 (3.3%)

3 (3.1%)

5 (2.7%)

0.598

4 (2.5%)

0 (0%)

1 (8.3%)

5 (2.3%)

0.231

HPV51

0 (0%)

0 (0%)

0 (0%)

0 (0%)

–

1 (3.2%)

2 (3.3%)

1 (1%)

4 (2.1%)

0.567

3 (1.9%)

0 (0%)

1 (8.3%)

4 (1.9%)

0.171

HPV18

0 (0%)

5 (23.8%)

0 (0%)

5 (19.2%)

0.479

7 (22.6%)

21 (35%)

31 (32.3%)

59 (31.6%)

0.470

45 (28.5%)

15 (34.9%)

4 (33.3%)

64 (30%)

0.696

HPV35

0 (0%)

7 (33.3%)

1 (100%)

8 (30.8%)

0.129

7 (22.6%)

21 (35%)

31 (32.3%)

59 (31.6%)

0.470

49 (31%)

14 (32.6%)

4 (33.3%)

67 (31.5%)

0.971

HPV59

0 (0%)

10 (47.6%)

1 (100%)

11 (42.3%)

0.103

15 (48.4%)

27 (45%)

33 (34.4%)

75 (40.1%)

0.247

66 (41.8%)

18 (41.9%)

2 (16.7%)

86 (40.4%)

0.227

HPV68

1 (25%)

4 (19%)

0 (0%)

5 (19.2%)

0.850

2 (6.5%)

3 (5%)

10 (10.4%)

15 (8%)

0.451

17 (10.8%)

3 (7%)

0 (0%)

20 (9.4%)

0.389

HPV33

1 (25%)

5 (23.8%)

0 (0%)

6 (23.1%)

0.854

6 (19.4%)

2 (3.3%)

8 (8.3%)

16 (8.6%)

0.035

15 (9.5%)

6 (14%)

1 (8.3%)

22 (10.3%)

0.677

HPV45

0 (0%)

5 (23.8%)

0 (0%)

5 (19.2%)

0.479

3 (9.7%)

4 (6.7%)

10 (10.4%)

17 (9.1%)

0.725

15 (9.5%)

5 (11.6%)

2 (16.7%)

22 (10.3%)

0.698

HPV66

0 (0%)

5 (23.8%)

0 (0%)

5 (19.2%)

0.479

4 (12.9%)

4 (6.7%)

9 (9.4%)

17 (9.1%)

0.612

16 (10.1%)

5 (11.6%)

1 (8.3%)

22 (10.3%)

0.934

HPV52

0 (0%)

1 (4.8%)

0 (0%)

1 (3.8%)

0.884

1 (3.2%)

4 (6.7%)

10 (10.4%)

15 (8%)

0.394

10 (6.3%)

4 (9.3%)

2 (16.7%)

16 (7.5%)

0.375

HPV53

0 (0%)

1 (4.8%)

0 (0%)

1 (3.8%)

0.884

0 (0%)

0 (0%)

1 (1%)

1 (0.5%)

0.621

1 (0.6%)

1 (2.3%)

0 (0%)

2 (0.9%)

0.559

HPV56

0 (0%)

2 (9.5%)

0 (0%)

2 (7.7%)

0.773

2 (6.5%)

2 (3.3%)

2 (2.1%)

6 (3.2%)

0.486

7 (4.4%)

1 (2.3%)

0 (0%)

8 (3.8%)

0.634

HPV58

0 (0%)

0 (0%)

0 (0%)

0 (0%)

–

4 (12.9%)

2 (3.3%)

3 (3.1%)

9 (4.8%)

0.070

8 (5.1%)

1 (2.3%)

0 (0%)

9 (4.2%)

0.552

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