Table 3 Distribution of mutations associated with resistance to NRTIs, NNRTIs, and PIs

Major Mutations PIs

36

40

M46I

11

12.2

I84V

6

6.7

V82A

6

6.7

I54V

4

4.4

I47V

3

3.3

L76V

3

3.3

L90M

2

2.2

I50V

1

1.1

Minor mutations PIs

54

60

K20I

14

15.6

L10F/I/V

13

14.5

L33F

5

5.6

T74P/S

5

5.6

F53L/Y

4

4.5

A71T/V

3

3.3

L89V

3

3.3

Q58E

2

2.2

I15V

1

1.1

I84I/M

1

1.1

K43T

1

1.1

M361

1

1.1

Codons

N = 148

%

Mutations RNTIs

Non TAMs

45

30.4

M184V

43

29.1

L74I/V

12

8.1

TAMs

K215F/V

22

14.9

D67DN/E/G/N/T

15

10.1

T219N/Q/Y

10

6.7

K65R

6

4

T69N

4

2.7

V75I

3

2

E44D

2

1.3

Y115F

2

1.3

A62V

1

0.8

Codons

N = 104

%

Mutations NNRTIs

K103N/S

34

32.7

V108I

11

10.6

A98G

11

10.6

P225H

10

9.6

H221Y

6

5.8

Y188L

6

5.8

G190A

6

5.8

Y181C

5

4.8

E138A/Q

4

3.8

K101P

3

2.9

V106I

3

2.9

V197T/VE

3

2.9

M230L

1

0.9

K238T

1

0.9