Table 3 Minor Allele Frequencies of single nucleotide polymorphism (SNP) of IL17-A gene and association analysis with severe outcomes. The p values for statistical tests were performed using each polymorphism's linear regression model analysis. Association analysis of IL-17A was served separately, and corrections to each other were applied to reflect the real effect of each. Analysis has been carried out by comparing SM vs UM, UM vs CTR, and SM vs CTR. Borderline (0.05 ≤ p ≤ 0.1) and significant (0 −  ≤ p ≤ 0.05) p values are in bold. *The OR (odds ratio) and CI (Confidence intervals) were shown when p values were significant for malaria (SM)
SNP | Gene location | NCBI dbSNP number | MAF | HWE, exact P-value | Â | ||||
|---|---|---|---|---|---|---|---|---|---|
CTR | UM | SM | Global | SM vs UM | UM vs CTR | SM vs CTR | |||
+ 521 (A > C) | 5 Prime UTR | rs9791323 | 0.033 | 0.113 | 0.075 | 0.075 | 0.37 | 0.045 3.78 (2.13 – 7.8)* | 0.2477 |
+ 606 (A > G) | 5 Prime UTR | rs3819024 | 0.239 | 0.113 | 0.25 | 0.203 | 0.007 2.61 (1.16 – 5.21)* | 0.02 | 0.876 |
+ 849 (G > A) | 5 Prime UTR | rs2275913 | 0.053 | 0.028 | 0.079 | 0.055 | 0.15 | 0.48 | 0.59 |
+ 973 (G > A) | 5 Prime UTR | rs8193037 | 0.021 | 0.009 | 0.024 | 0.018 | 0.63 | 0.60 | 1 |
+ 1090 (G > A) | intron_variant | rs3819025 | 0.085 | 0.104 | 0.095 | 0.096 | 0.83 | 0.81 | 1 |
+ 1198 (A > G) | intron_variant | rs8193038 | 0.021 | 0.009 | 0.024 | 0.018 | 0.63 | 0.60 | 1 |
+ 3840 (G > A) | coding_sequence | rs17880588 | 0.053 | 0.034 | 0.043 | 0.043 | 1 | 0.67 | 1 |
+ 5151 (C > T) | 3 Prime UTR Variant | rs3748067 | 0.125 | 0.055 | 0.155 | 0.112 | 0.04 0.32 (0.15 – 0.90)* | 0.10 | 0.54 |