Table 6 Specific RdRp single nucleotide variants of SARS-CoV-2 correlated with the severity of COVID-19 according to GISAID database

SNV

AA

A (n = 14,938)

H (n = 83,979)

OR

95% CI

RR

95% CI

p-value

14676C > T

P412P

512 (3.4%)

6998 (8%)

2.56

2.33–2.80

1.12

1.09–1.11

< 0.0001

14697C > T

F419F

10 (0.06%)

35 (0.04%)

1.61

0.77–3.24

1.09

0.97–1.33

0.18

15,096 T > C

N552N

74 (0,49%)

1704 (2%)

4.13

3.27–5.21

1.13

1.12–1.14

< 0.0001

15240C > T

N600N

951 (6.3%)

13,261 (15%)

2.76

2.57–2.95

1.12

1.11–1.12

< 0.0001

15279C > T

H613H

501 (3.35%)

7011 (8.3%)

2.62

2.39–2.87

1.11

1.10–1.12

< 0.0001

SNV

AA

A (n = 14,938)

severe (n = 955)

OR

95% CI

RR

95% CI

p-value

14676C > T

P412P

512 (3.4%)

64 (6.7%)

2.02

1.54–2.63

1.9

1.50–2.41

< 0.0001

14697C > T

F419F

10 (0.06%)

0 (0.00%)

–

–

–

–

–

15,096 T > C

N552N

74 (0,49%)

24 (2.51%)

5.2

3.29–8.21

4.17

2.89–5.81

< 0.0001

15240C > T

N600N

951 (6.3%)

79 (8.27%)

1.33

1.05–1.68

1.30

1.04–1.62

0.02

15279C > T

H613H

< 0.0001