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Table 3 Specific RdRp single nucleotide variants of SARS-CoV-2 correlated with the risk of hospitalization of COVID-19 patients

From: The RdRp genotyping of SARS-CoV-2 isolated from patients with different clinical spectrum of COVID-19

SNV

AA

1st (n = 33)

H (n = 44)

1st correlated with H

 

OR

95% CI

RR

95% CI

p-value

14676C > T

P412P

1

25

42.10

5.27–336.30

18.75

2.67–131.41

< 0.0001

14697C > T

F419F

0

14

31.85

1.82–557.08

21.91

1.35–354.54

0.0002

15,096 T > C

N552N

1

14

15.93

1.84–120.61

10.50

1.45–75.89

0.0013

15240C > Ta

N600N

19

0

119.68

6.79–2108.97

51.61

3.22–825.07

< 0.0001

15279C > T

H613H

2

29

29.96

6.29–142.59

10.87

2.79–42.37

< 0.0001

  1. 1st – number of asymptomatic COVID-19 patients (outpatients), H number of hospitalized (2nd, 3rd and 4th spectrum) COVID-19 patients (inpatients), n number of all COVID-19 patients in the group, OR odds ratio between groups, RR relative risk between groups (1st vs. H), CI Confidence interval, SNV single nucleotide variant, AA Amino acid variant; p-value was measured by Fisher’s exact test, two-sided, p < 0.05, was considered statistically significant; zero values were treated as 0.5; a - negative correlation