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Table 2 Prognostic factors by mutation type of SARS-CoV-2

From: Evaluation of characteristics and prognosis of COVID-19 patients requiring invasive mechanical ventilation during dominance of nonvariant, alpha, delta, and omicron variants in tertiary hospitals of Japan

Prognostic factor

Nonvariant

n = 118

Alpha

n = 154

Delta

n = 42

Omicron

n = 63

Peak LDH, U/L, (range)

536 (415–751)

529 (435–673)

538 (458–761)

544 (408–793)

Peak KL-6, U/ml, (range)

809 (514–1410)

795 (485–1359)

505 (386–823)

730 (502–1299)

Peak β-D Glucan ≥ 20 pg/ml, n (%)

24 (20.3)

34 (22.1)

5 (11.9)

18 (28.6)

Positive blood culture, n (%)

20 (16.9)a

21 (13.6)a

2 (4.8)a

34 (54.0)

Ventilator-free days, days, (range)

17 (0–21)

17 (0–21)

16 (4–19)

0 (0–19)

Barotrauma, n (%)

13 (11.0)

18 (11.7)

0

4 (6.3)

Tracheostomy, n (%)

23 (19.5)

41 (26.6)

10 (23.8)

23 (36.5)

In-hospital mortality, n (%)

28 (23.7)

19 (12.3)a

3 (7.1)

19 (30.5)

Causes of death

    

 Covid-19 pneumonia, n

26

18

2

14

 Others, n

Bacterial pneumonia, 1

Lung cancer, 1

Heart failure, 1

Bacterial sepsis, 1

Bacterial sepsis, 2

Bacterial pneumonia, 1

Duodenal bleeding, 1

Intestinal necrosis, 1

  1. aSignificant difference between the group and the Omicron group on post-hoc test. LDH lactate dehydrogenase, KL-6 sialylated carbohydrate antigen KL-6