Table 5 Factors associated with mortality in patients with bloodstream infections by Cox proportional hazards analysis

Age

1.00

1.00, 1.01

0.033

Sex, male

1.16

1.03, 1.30

0.012

BMI

0.99

0.97, 1.00

0.072

Community-onset sepsis

0.99

0.87, 1.13

> 0.9

Polymicrobial bloodstream infections

1.15

0.97, 1.36

0.11

Cardiovascular disease

1.01

0.88, 1.15

0.9

Chronic lung disease

1.11

0.92, 1.33

0.3

Chronic neurological disease

0.81

0.70, 0.94

0.007

0.70

0.59, 0.82

< 0.001

Chronic liver disease

1.08

0.92, 1.28

0.3

Diabetes

0.91

0.81, 1.03

0.12

Chronic kidney disease

1.27

1.09, 1.49

0.002

Connective tissue disease

0.71

0.48, 1.07

0.10

Immunocompromised

1.10

0.84, 1.44

0.5

Hematological malignancies

1.46

1.22, 1.74

< 0.001

1.46

1.20, 1.77

< 0.001

Solid malignant tumors

1.37

1.23, 1.54

< 0.001

1.30

1.12, 1.52

< 0.001

Charlson comorbidity index

1.08

1.06, 1.11

< 0.001

1.04

1.01, 1.07

0.005

ECOG score

1.29

1.24, 1.35

< 0.001

1.08

0.99, 1.19

0.10

CFS score

1.18

1.15, 1.22

< 0.001

1.14

1.08, 1.21

< 0.001

Source of infection

 Pulmonary

1.75

1.55, 1.98

< 0.001

1.41

1.22, 1.62

< 0.001

 Abdominal

0.85

0.75, 0.96

0.010

 Urinary

0.51

0.44, 0.60

< 0.001

0.55

0.46, 0.65

< 0.001

 Skin and soft tissue

1.07

0.83, 1.38

0.6

 Catheter-related

0.90

0.64, 1.26

0.5

 Systemic infections

1.63

1.39, 1.91

< 0.001

1.38

1.15, 1.66

 < 0.001

 Neurologic

0.48

0.18, 1.27

0.14

Initial septic shock

1.56

1.38, 1.76

< 0.001

1.55

1.37, 1.76

< 0.001

Inappropriate use of antibiotics

1.60

1.39, 1.83

< 0.001

1.37

1.19, 1.57

< 0.001

Source control

0.45

0.38, 0.54

< 0.001

0.51

0.42, 0.62

< 0.001