Table 4 Treatment and outcomes of polymicrobial bloodstream infections vs. monomicrobial bloodstream infections in patients with sepsis
Variable | Monomicrobial bloodstream infections (n = 3394) | Polymicrobial bloodstream infections (n = 429) | P-value |
|---|---|---|---|
Appropriate use of antibiotics, n (%) | 2834 (83.7) | 343 (80.3) | 0.091 |
Inappropriate use of antibiotics, n (%) | 552 (16.3) | 84 (19.7) | 0.091 |
Infection source control, n (%) | 603 (17.8) | 107 (24.9) | < 0.001 |
Surgical | 119 (3.5) | 14 (3.3) | 0.905 |
Non-surgical | 488 (14.4) | 95 (22.1) | < 0.001 |
Percutaneous drainage | 414 (12.2) | 84 (19.6) | < 0.001 |
Pleural | 22 (5.3) | 0 (0.0) | 0.062 |
Hepatobiliary | 296 (71.5) | 74 (88.1) | 0.002 |
Peritoneal | 31 (7.5) | 5 (6.0) | 0.791 |
Others | 65 (15.7) | 5 (6.0) | 0.030 |
ICU admission, n (%) | 1543 (45.5) | 209 (48.7%) | 0.221 |
ICU length of stay, days, median (IQR) | 5.0 (3.0–8.0) | 5.0 (3.0–10.0) | 0.209 |
ICU mortality, n (%) | 401 (26.0) | 62 (29.7) | 0.295 |
SAPS3, mean ± SD | 74.5 ± 16.3 | 80.3 ± 15.6 | < 0.001 |
MV apply, n (%) | 681 (20.1) | 121 (28.2) | < 0.001 |
MV duration, days, median (IQR) | 4.0 (2.0–11.0) | 5.0 (3.0–11.0) | 0.105 |
CRRT apply, n (%) | 466 (13.7) | 77 (17.9) | 0.022 |
ECMO apply, n (%) | 12 (0.4) | 3 (0.7) | 0.503 |
Hospital length of stay, days, median (IQR) | 15.0 (8.0–27.0) | 17.0 (9.0–30.0) | 0.025 |
Hospital mortality, n (%) | 1021 (30.1) | 153 (35.7) | 0.021 |
28-day mortality, n (%) | 903 (29.1) | 135 (34.0) | 0.049 |