Table 1 Characteristics of polymicrobial bloodstream infections vs. monomicrobial bloodstream infections in patients with sepsis
Variable | Monomicrobial bloodstream infections (n = 3394) | Polymicrobial bloodstream infections (n = 429) | P-value |
|---|---|---|---|
Age, median(IQR) | 73.0 (62.0–81.0) | 72.0 (64.0–79.0] | 0.297 |
Sex, n(%) | 1850 (54.5) | 253 (59.0) | 0.089 |
BMI, mean ± SD | 22.2 ± 4.1 | 21.8 ± 3.9 | 0.033 |
Community-onset sepsis, n(%) | 2708 (79.8) | 327 (76.2) | 0.098 |
Hospital-onset sepsis, n(%) | 686 (20.2) | 102 (23.8) | 0.098 |
Medical ICU | 539 (78.6) | 67 (65.7) | 0.006 |
Surgical ICU | 147 (21.4) | 35 (34.3) | 0.006 |
Comorbidity, n(%) | |||
Cardiovascular disease | 763 (22.5) | 91 (21.2) | 0.594 |
Chronic lung disease | 346 (10.2) | 38 (8.9) | 0.434 |
Chronic neurological disease | 710 (20.9) | 106 (24.7) | 0.081 |
Chronic liver disease | 397 (11.7) | 48 (11.2) | 0.819 |
Diabetes | 1199 (35.3) | 162 (37.8) | 0.348 |
Chronic kidney disease | 419 (12.3) | 54 (12.6) | 0.948 |
Connective tissue disease | 83 (2.4) | 14 (3.3) | 0.394 |
Immunocompromised | 114 (3.4) | 22 (5.1) | 0.084 |
Hematological malignancies | 274 (8.1) | 30 (7.0) | 0.494 |
Solid malignant tumors | 1274 (37.5) | 230 (53.6) | < 0.001 |
Charlson comorbidity index, mean ± SD | 5.7 ± 2.6 | 6.2 ± 2.4 | < 0.001 |
ECOG > = 2, n(%) | 2030 (59.8) | 274 (63.9) | 0.117 |
CFS score, mean ± SD | 5.1 ± 2.2 | 5.2 ± 2.2 | 0.117 |
Source of infection, n(%) | |||
Pulmonary | 899 (26.5) | 84 (19.6) | 0.002 |
Abdominal | 1166 (34.4) | 235 (54.8) | < 0.001 |
Urinary | 992 (29.2) | 67 (15.6) | < 0.001 |
Skin and soft tissue | 145 (4.3) | 19 (4.4) | 0.981 |
Catheter-related | 86 (2.5) | 10 (2.3) | 0.929 |
Systemic infections | 369 (10.9) | 38 (8.9) | 0.233 |
Neurologic | 15 (0.4) | 4 (0.9) | 0.319 |
Initial septic shock, n(%) | 765 (22.5) | 113 (26.3) | 0.089 |
SOFA score at time zero, mean ± SD | 6.9 ± 3.2 | 7.5 ± 3.2 | < 0.001 |
Lactate, mmol/L, mean ± SD | 4.4 ± 3.5 | 5.2 ± 3.5 | < 0.001 |