Age difference of patients with and without invasive aspergillosis: a systematic review and meta-analysis

Shekhova, Elena; Salazar, Fabián; Da Silva Dantas, Alessandra; Chakraborty, Tanmoy; Wooding, Eva L.; White, P. Lewis; Warris, Adilia

doi:10.1186/s12879-024-09109-2

BMC Infectious Diseases

Table 1 Overview of included studies

From: Age difference of patients with and without invasive aspergillosis: a systematic review and meta-analysis

Publication	Underlying condition	ICU	Prophylaxis^a	Sample size	Study design	IA type^b	Start year	End year
Feys et al., 2023 [92]	COVID-19	YES	NO	335	cohort	mixed	2020	2022
Hurt et al., 2023 [86]	COVID-19	YES	NO	266	cohort	probable	2020	2021
Dai et al., 2023 [82]	Hematologic disease	NO	NO	189	cohort	mixed	2011	2021
Dubler et al., 2023 [93]	Critically ill	YES	YES	121	cohort	putative	2015	2019
Grootveld et al., 2023 [83]	COVID-19	YES	NO	793	cohort	mixed	2020	2021
Song et al., 2023 [80]	Hematologic disease	NO	NO	67	cohort	probable	2021	2022
Waldeck et al., 2023 [81]	Influenza	YES	NO	158	cohort	mixed	2017	2020
Lee et al., 2022 [90]	COVID-19	NO	NO	228	cohort	mixed	2020	2021
Kim et al., 2022 [72]	COVID-19	YES	NO	187	cohort	mixed	2020	2021
Er et al., 2022 [74]	COVID-19	YES	NO	213	cohort	mixed	2020	2021
Calderon-Parra et al., 2022 [76]	COVID-19	YES	NO	84	case-control	mixed	2020	2021
Bentvelsen et al., 2022 [88]	COVID-19	YES	NO	123	case-control	mixed	2020	2020
de Almeida et al., 2022 [78]	COVID-19	YES	NO	56	case-control	mixed	2020	2021
Xu et al., 2021 [77]	COVID-19	YES	NO	335	cohort	mixed	2019	2020
Chao et al., 2021 [84]	Influenza	YES	NO	90	cohort	mixed	2016	2018
Apostolopoulou et al., 2021 [91]	Organ transplantation	NO	NO	224	cohort	mixed	2011	2017
Katada et al., 2022 [89]	Organ transplantation	NO	YES	120	case-control	mixed	2011	2016
Janssen et al., 2021 [87]	COVID-19	YES	NO	279	cohort	mixed	2020	2020
Prattes et al., 2022 [85]	COVID-19	YES	NO	592	cohort	mixed	2020	2021
Le Pavec et al., 2021 [75]	Organ transplantation	NO	NO	191	cohort	mixed	2013	2017
Gu et al., 2021 [73]	COPD	NO	NO	616	cohort	mixed	2012	2017
Lahmer et al., 2021 [79]	COVID-19	YES	NO	32	case-control	putative	2020	2020
Xu et al., 2021 [77]	Hematologic disease	NO	NO	91	cohort	mixed	2016	2019
Razazi et al., 2020 [44]	ARDS	YES	NO	172	cohort	putative	2009	2020
Delliere et al., 2021 [41]	COVID-19	YES	NO	108	cohort	probable	2020	2020
Chauvet et al., 2020 [39]	COVID-19	YES	NO	46	cohort	putative	2020	2020
Bellelli et al., 2020 [42]	Influenza	NO	NO	77	cohort	NR	2018	2019
Chen et al., 2020 [37]	Pneumonia	NO	NO	693	cohort	mixed	2018	2018
Waldeck et al., 2020 [36]	Influenza	YES	NO	81	cohort	NR	2017	2018
Seok et al., 2020 [46]	Organ transplantation	NO	NO	78	case-control	probable	1995	2015
Zou et al., 2020 [62]	Pneumonia	NO	NO	335	cohort	probable	2013	2018
Sharma et al., 2020 [56]	Influenza	NO	NR	477,556	cohort	NR	2005	2014
Lahmer et al., 2019 [35]	Liver disease	YES	NO	84	cohort	probable	NR	NR
Tejerina et al., 2019 [43]	Critically ill	YES	NO	878	cohort	proven	1991	2016
Napolioni et al., 2019 [31]	Hematologic disease	NO	NO	352	cohort	NR	NR	NR
Bitterman et al., 2019 [48]	Hematologic disease	NO	NO	107	cohort	proven	2015	2018
Levesque et al., 2019 [29]	Liver disease	YES	NO	208	case-control	mixed	2005	2015
Huang et al., 2019 [57]	Influenza	YES	NO	109	case-control	mixed	2017	2018
Herrera et al., 2019 [52]	Organ transplantation	NO	NO	23	case-control	mixed	2016	2016
Cook et al., 2018 [60]	Organ transplantation	NO	NO	69	case-control	mixed	1986	2015
Rodriguez-Goncer et al., 2018 [51]	Critically ill	YES	NO	125	cohort	putative	2012	2016
Kaya et al., 2017 [47]	Hematologic disease	NO	YES	152	case-control	mixed	2010	2012
Zhang et al., 2018 [59]	Liver disease	NO	NO	1077	cohort	NR	2011	2016
White et al., 2017 [33]	Hematologic disease	NO	NO	274	cohort	proven	2005	2009
Lopez-Medrano et al., 2018 [50]	Organ transplantation	NO	NO	122	case-control	mixed	2000	2013
Lopez-Medrano et al., 2016 [65]	Organ transplantation	NO	NO	102	case-control	mixed	2000	2013
Nagao et al., 2016 [53]	Liver disease	NO	YES	30	case-control	mixed	2007	2013
Heylen et al., 2015 [45]	Organ transplantation	NO	NO	123	case-control	mixed	1995	2013
Kurosaki et al., 2014 [40]	Pneumonia	NO	NO	539	cohort	proven	2006	2012
Gustot et al., 2014 [68]	Liver disease	YES	NO	94	cohort	mixed	2006	2012
Luong et al., 2014 [38]	Organ transplantation	YES	YES	93	cohort	mixed	2006	2010
Chen et al., 2013 [49]	Liver disease	YES	NO	87	case-control	mixed	2008	2012
Schwarzinger et al., 2013 [70]	Hematologic disease	NR	YES	185	cohort	mixed	2003	2006
Wauters et al., 2012 [54]	Pneumonia	YES	NO	40	cohort	mixed	2009	2011
Xu et al., 2012 [61]	COPD	NO	NO	90	case-control	probable	2006	2009
Michallet et al., 2012 [34]	Hematologic disease	NO	NO	261	cohort	mixed	2004	2007
Michallet et al., 2011 [30]	Hematologic disease	NO	YES	117	case-control	probable	2006	2008
Mikulska et al., 2009 [32]	Hematologic disease	NO	YES	304	cohort	mixed	1999	2006
Kontoyiannis et al., 2007 [71]	Hematologic disease	NR	YES	66	case-control	NR	2002	2004
Garnacho-Montero et al., 2005 [55]	Critically ill	YES	NO	756	cohort	mixed	1998	1999
Muhlemann et al., 2005 [69]	Hematologic disease	NO	YES	142	cohort	proven	1995	1999
Fukuda et al., 2004 [64]	Hematologic disease	NO	YES	2319	cohort	mixed	1992	2001
Thursky et al., 2004 [67]	Hematologic disease	NR	YES	206	cohort	mixed	1991	1998
Munoz et al., 2004 [63]	Organ transplantation	NO	YES	278	cohort	mixed	1998	2002
Hahn et al., 2002 [66]	Hematologic disease	NR	YES	35	cohort	mixed	1992	1992

ICU intensive care unit, ARDS acute respiratory distress syndrome, NR not reported, COPD chronic obstructive pulmonary disease
^aProphylaxis was stated as YES even when administrated only by a portion of patients, the following agents were used for antifungal prophylaxis: [93]: fluconazole/caspofungin; [89]: itraconazole; [47]: posaconazole; [53]: fluconazole/micafungin; [38]: amphotericin B/voriconazole/itraconazole; [30]: posaconazole; [32]: fluconazole, fluconazole/amphotericin B, amphotericin B, voriconazole; [64]: fluconazole/itraconazole; [67]: fluconazole/itraconazole; [63]: itraconazole; [70]: amphotericin B/fluconazole/itraconazole; [71]: NA; [66]: itraconazole; [58]: posaconazole; [69]: fluconazole
^bIn the data collection process, the IA type was recorded as mixed when the age of patients was not specifically categorized or stratified based on the IA classification

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