Table 1 Baseline characteristics of cases with carbapenem-resistant Enterobacterales infection reported to the National Epidemiological Surveillance of Infectious Diseases

Age, median [IQR]

76 [67–83]

77 [68–84]

78 [69–85]

76 [67–84]

0.085

Male (N, %)

1045 (62.2%)

454 (61.4%)

112 (57.1%)

342 (62.9%)

0.171

Type of infection (N, %)

Urinary tract infection

542 (32.2%)

244 (33.0%)

76 (38.8%)

168 (30.9%)

0.051

Bloodstream infection

491 (29.2%)

208 (28.1%)

64 (32.7%)

144 (26.5%)

0.115

Intra-abdominal infection

454 (27.0%)

207 (28.0%)

31 (15.8%)

176 (32.4%)

< 0.001

Respiratory tract infection

368 (21.9%)

171 (23.1%)

53 (27.0%)

118 (21.7%)

0.913

Bone and soft tissue infection

138 (8.2%)

61 (8.2%)

16 (8.2%)

45 (8.3%)

1.000

Others

16 (1.0%)

6 (0.8%)

1 (0.5%)

5 (0.9%)

1.000

Not specified

5 (0.3%)

2 (0.3%)

0 (0%)

2 (0.4%)

0

Multiple types of infection

305 (18.1%)

144 (19.5%)

40 (20.4%)

104 (19.1%)

0.752

Bacterial species (N, %)

Klebsiella aerogenes

595 (35.4%)

241 (32.6%)

0 (0%)

241 (44.3%)

< 0.001

Enterobacter cloacae complex

487 (29.0%)

202 (27.3%)

60 (30.6%)

142 (26.1%)

0.226

Klebsiella pneumoniae

165 (9.8%)

86 (11.6%)

53 (27.0%)

33 (6.1%)

< 0.001

Escherichia coli

129 (7.7%)

68 (9.2%)

38 (19.4%)

30 (5.5%)

< 0.001

Serratia marcescens

71 (4.2%)

29 (3.9%)

4 (2.0%)

25 (4.6%)

0.135

Others

192 (11.4%)

97 (13.1%)

37 (18.9%)

60 (11.0%)

0.007

Not reported

48 (2.9%)

18 (2.4%)

4 (2.0%)

14 (2.6%)

0.793

Detected carbapenemase gene (N, %)

bla_IMP

–

183 (24.7%)

183 (93.4%)

–

–

bla_NDM^a

–

8 (1.1%)

8^a (4.1%)

–

–

bla_KPC^b

–

5 (0.7%)

5^b (2.6%)

–

–

bla_OXA-48-like

–

0 (0%)

0 (0%)

–

–

Cases with reported date of death (N, %)

68 (4.0%)

33 (4.5%)

12 (6.1%)

21 (3.9%)

0.225