Table 7 Details overview of the discordant results
ProSPeRo | Before enrollment | Interpretation | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N | Enrollment date | Syphilis signs/symptoms | Local treponemal screening test: type, date, result | Local treponemal confirmatory test: type, date, result | Verona CLIA result | Verona TPPA result | Verona RPR result | Verona WB (interpretation) | Verona IB (interpretation) | HIV serostatus | Previous syphilis diagnosis (year) | Treponemal tests at diagnosis: type, date, result (carried out at local level) | Syphilis test: type, date, result (carried out at local level) | Syphilis signs/symptoms at first screening | CLIA result |
1 | 28/11/19 | No | TPHA, 11/2019, negative | NA | pos | neg | neg | TpN17 ± (neg) | TpN17 + , TpN15 ± TmpA ± (pos) | pos (2002) | Yes (2017) | NA | EIA 06/20, pos, VDRL 1:16, TPHA 1:10240 | Yes | True positive |
2 | 25/09/18 | No | CLIA, 01/18, pos | TPHA, 01/18, 1:80 | pos | neg | neg | TpN47 + (indet) | TpN47 + , TpN17 + (pos) | neg | Yes (2017) | TPHA, 17, 1:640 | EIA, 04/19, pos, VDRL 1:256 | Yes | True positive |
3 | 02/10/18 | No | CLIA, 10/18, neg | NA | neg | pos | neg | neg | Neg | neg | No | NA | EIA, 10/19, neg | NA | True negative |
4 | 13/08/18 | No | CLIA, 08/18, neg | NA | pos | neg | neg | neg | Not performed (no leftover) | neg | No | NA | EIA, 04/19, neg | No | False positive |
5 | 01/03/19 | No | CLIA, 03/19, neg | NA | pos | neg | neg | neg | TpN17 ± (neg) | pos | No | NA | EIA, 12/20, neg | No | False positive |
6 | 27/03/19 | No | CLIA, 03/19, neg | NA | pos | neg | neg | neg | TpN17 + , TmpA ± (pos) | pos | No | NA | EIA 12/20, neg | No | Probable previous (undiagnosed) infection |
7 | 25/11/19 | No | TPHA, 11/2019, negative | NA | pos | neg | neg | TmpA ± (neg) | TpN17 + TmpA + (pos) | pos (05/2015) | Yes (2015) | TPHA, 15, 1:160 | EIA 07/20, neg | No | True positive |
8 | 06/09/18 | No | NA | TPHA, 09/18, 1:80 | pos | neg | neg | neg | TpN47 + TpN17 + + (pos) | neg | Yes (2004) | TPHA, 04, 1:80 | NA | NA | True positive |