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Table 1 Patient characteristics

From: The risk factors associated with post-transplantation BKPyV nephropathy and BKPyV DNAemia: a prospective study in kidney transplant recipients

 

FAS (n = 205)

FAS BKPyVAN

or high (n = 35)

FAS non BKPyVAN

or high (n = 170)

PP (n = 159)

PP BKPyVAN

or high (n = 34)

PP non BKPyVAN

or high (n = 125)

BKPyVAN (n = 10)

BKPyVAN

10 (4.9)

  

10 (6.3)

   

Time to BKPyV (d)

83.5

93

 

83.5

92.5

 

83.5

Male sex

134 (65.4)

29 (82.3)

105 (61.8)

106 (66.7)

28 (82.4)

78 (62.4)

10 (100.0)

Age

54.8

60.3

53.7

56.1

59.8

55.1

57.4

Weight

78.2

82.1

77.4

77.7

82.4

76.5

84.5

Height

173.1

174.8

172.8

173.0

175.0

172.5

177.8

BMI

26.1

26.8

26.0

26.0

26.8

25.8

26.8

Diabetes

44 (21.5)

9 (24.3)

35 (20.8)

39 (24.5)

9 (25.0)

30 (24.4)

3 (30.0)

Primary cause of renal failure

       

Glomerulonephritis

49 (23.9)

7 (18.9)

42 (25.0)

35 (22.0)

7 (19.4)

28 (22.8)

3 (30.0)

Diabetes

37 (18.0)

8 (21.6)

29 (17.3)

33 (20.6)

8 (22.2)

25 (20.3)

3 (30.0)

Cystic/Hereditary/

Congenital

24 (11.7)

4 (10.8)

20 (11.9)

17 (10.7)

4 (11.1)

13 (10.6)

1 (10.0)

Hypertension/Large vessel disease

31 (15.1)

7 (20.0)

24 (14.1)

25 (15.7)

7 (20.6)

18 (14.4)

1 (10.0)

Miscellaneous/unknown

57 (27.8)

8 (22.6)

49 (28.8)

44 (27.7)

7 (20.6)

37 (29.6)

2 (20.0)

Interstitial nephritis/pyelonephritis

6 (2.9)

1 (2.7)

5 (3.0)

4 (2.5)

1 (2.8)

3 (2.4)

0 (0)

Vasculitis/Secondary glomerulonephritis

1 (0.5)

0 (0)

1 (0.6)

1 (0.6)

0 (0)

1 (0.8)

0 (0)

Simultaneous pancreas tx

2 (1.0)

1 (2.7)

1 (0.6)

2 (1.3)

1 (2.8)

1 (0.8)

1 (10.0)

ABO incompatible

21 (10.2)

4 (10.8)

17 (10.1)

16 (10.1)

4 (11.1)

12 (9.8)

0 (0)

First tx

187 (91.2)

32 (91.4)

155 (91.2)

147 (92.5)

31 (91.2)

116 (92.8)

10 (100.0)

Second tx

16 (7.8)

3 (8.1)

13 (7.7)

11 (6.9)

3 (8.3)

8 (6.5)

0 (0)

Third or more tx

2 (1.0)

0 (0)

2 (1.2)

1 (0.6)

0 (0)

1 (0.8)

0 (0)

Living donor

73 (35.6)

10 (27.0)

63 (37.5)

51 (32.1)

10 (27.8)

41 (33.3)

1 (10.0)

Donor age

54.4

61.1

53.0

56.4

60.8

55.2

59.4

Donor male sex

99 (48.3)

15 (42.3)

84 (49.4)

78 (49.1)

15 (44.1)

63 (50.4)

4 (40.0)

Recipient CMV+

138 (67.3)

24 (68.6)

114 (67.1)

107 (67.3)

23 (67.6)

84 (67.2)

5 (50.0)

Donor CMV+

149 (72.7)

30 (85.7)

119 (70.0)

115 (72.3)

29 (85.3)

86 (68.8)

8 (80.0)

CMV mismatch (d+/r-)

44 (21.5)

10 (27.0)

34 (20.2)

36 (22.6)

10 (27.8)

26 (21.1)

4 (40.0)

Delayed graft function (d)

1.9

2.1

1.9

2.0

2.1

2.0

1.9

Enhanced induction

31 (15.1)

5 (13.5)

26 (15.5)

23 (14.5)

5 (13.9)

18 (14.6)

1 (10.0)

Rejection treatment

48 (23.4)

10 (27.0)

38 (22.6)

40 (25.2)

9 (25.0)

31 (25.2)

5 (50.0)

SM-resistant rejection treatment

13 (6.3)

1 (2.7)

12 (7.1)

11 (6.9)

1 (2.8)

10 (8.1)

1 (10.0)

Graft loss or death

10 (4.9)

1 (2.7)

9 (5.4)

10 (6.3)

1 (2.8)

9 (7.3)

1 (10.0)

Death

3 (1.5)

0 (0)

3 (1.8)

3 (1.9)

0 (0)

3 (2.4)

0 (0)

  1. Demographics and clinical characteristics of kidney- and kidney/pancreas graft recipients with BKPyVAN or high-level DNAemia compared to those with low-level DNAemia or BKPyV negative graft recipients. The table also shows a breakdown of the Full analysis set (FAS) and those who followed the study Per protocol (PP). The number of patients with rejection treatment in this table is both prior to, concurrent with, and after developing BKPyVAN.