Table 2 Univariable and multivariable logistic analyzes for in-hospital mortality in patients with sepsis

Age (years), n(%)

18 ≤ age < 60

19,359 (21.1)

Reference

Reference

60 ≤ age < 70

17,215 (26.2)

1.326 (1.295–1.357)

< 0.001

1.402 (1.365–1.441)

< 0.001

70 ≤ age < 80

33,048 (28.7)

1.507 (1.477–1.538)

< 0.001

1.910 (1.864–1.957)

< 0.001

80 ≤ age

34,012 (34.1)

1.937 (1.898–1.977)

< 0.001

3.233 (3.153–3.315)

< 0.001

Sex, n(%)

Male

58,685 (31.4)

Reference

Reference

Female

45,246 (24.2)

0.698 (0.688–0.709)

< 0.001

0.842 (0.828–0.857)

< 0.001

Comorbidities, n(%)

Hypertension

55,427 (25.5)

0.807 (0.795–0.819)

< 0.001

0.627 (0.615–0.639)

< 0.001

Diabetes

22,206 (25.2)

0.839 (0.825–0.854)

< 0.001

0.873 (0.854–0.891)

< 0.001

Liver cirrhosis

9550 (34.5)

1.405 (1.369–1.442)

< 0.001

1.613 (1.564–1.664)

< 0.001

Chronic kidney disease

14,305 (28.0)

1.008 (0.987–1.029)

0.448

1.067 (1.040–1.096)

< 0.001

Malignancy

38,196 (33.3)

1.470 (1.448–1.458)

< 0.001

   locoregional solid tumor

33,717 (33.3)

1.435 (1.413–1.458)

< 0.001

1.832 (1.794–1.870)

< 0.001

   metastasis

7277 (38.4)

1.666 (1.616–1.717)

< 0.001

2.218 (2.050–2.208)

< 0.001

   hematological malignancies

5650 (33.4)

1.319 (1.276–1.363)

< 0.001

2.095 (2.014–2.179)

< 0.001

Elixhauser comorbidity index

NA

   index < 10

Reference

Reference

   10 ≤ index < 20

1.393 (1.365–1.421)

< 0.001

1.156 (1.127–1.183)

< 0.001

   20 ≤ index < 30

1.552 (1.521–1.584)

< 0.001

1.161 (1.121–1.191)

< 0.001

   30 ≤ index

1.466 (1.435–1.498)

< 0.001

0.991 (0.963–1.020)

0.539

Insurance state, n(%)

   National health insurance

89,052 (27.5)

Reference

Reference

   Medical aid

14,879 (29.6)

1.105 (1.083–1.128)

< 0.001

1.205 (1.177–1.235)

< 0.001

ICU admission, n(%)

25,564 (39.9)

1.961 (1.927–1.996)

< 0.001

0.877 (0.852–0.903)

< 0.001

Mechanical ventilation, n(%)

NA

7.425 (7.306–7.545)

< 0.001

8.127 (7.969–8.288)

< 0.001

Continuous renal replacement therapy

15,910 (67.6)

6.203 (6.030–6.382)

< 0.001

3.152 (3.048–3.259)

< 0.001

Type of hospital, n(%)

   Tertiary hospitals

39,875 (27.0)

Reference

Reference

   General hospitals

64,056 (28.4)

1.092 (1.076–1.108)

< 0.001

1.390 (1.359–1.422)

< 0.001