Table 1 Summary of 9 case reports identified F.nucleatum bloodstream infection
Case | Country | Age(sex) | Medical history | WBC | CRP | Fever | Antibiotics | References |
|---|---|---|---|---|---|---|---|---|
1 | Japan | 59(M) | hypertension | High | High | Present | - Imipenem/cilastatin 500Â mg BD (4 days) - Oral clindamycin 600Â mg BD (UTP) | Kajiya et al., 2008 [11] |
2 | Canada | 24(M) | Healthy | High | N/A | Present | - IV metronidazole (4 weeks) - Oral metronidazole (2 weeks) | Cheung et al., 2007 [12] |
3 | France | 68(M) | lung tuberculosis, genitourinary tract tuberculosis, thrombocytopenia, and pulmonary embolisms | Low | High | Present | - IV cefotaxime 1Â g Q8H - IV metronidazole 500Â mg Q8H (24 days) - Oral metronidazole (2 weeks) - Enoxaparin 20Â mg daily (UTP) | Etienne et al., 2001 [13] |
4 | USA | 76(F) | hypertension, chronic obstructive pulmonary disease, and tobacco use disorder | N/A | N/A | Present | - vancomycin 15Â mg/kg Q12H) (4 days) - cefepime 2Â g Q12H (4 days) - metronidazole 500Â mg Q8H (4 days) | Swaminathan and Aguilar, 2020 [14] |
5 | Japan | 28(M) | Healthy | Low | High | Present | - Ceftriaxone (6 days) - Meropenem (14 days) | Takano et al., 2015 [15] |
6 | USA | 30(M) | Healthy | High | N/A | Present | - Piperacillin/tazobactam and metronidazole (UTP) - Oral levofloxacin and metronidazole (UTP) | Fatakhov et al., 2013 [16] |
7 | Japan | 44(M) | Healthy | High | High | Present | - Cefotiam (UTP) - Doripenem (19 days) - Oral levofloxacin (UTP) | Iwasaki et al., 2012 [17] |
8 | USA | 25(M) | Healthy | High | High | Present | - Piperacillin/tazobactam (UTP) - IV penicillin (6 weeks) | Handler et al., 2011 [18] |
9 | USA | 44(M) | paranoid schizophrenia, smoking, gonorrhea and trichomoniasis | High | N/A | Present | - IV ampicillin/sulbactam and ciprofloxacin (5 days) - IV ampicillin/sulbactam and metronidazole (13 days) - IV ampicillin/sulbactam (15 days) - Oral amoxicillin/clavulanate (1 month) | Treszezamsky et al., 2010 [19] |