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Table 2 The results of subgroup analysis

From: Clinical and diagnostic values of metagenomic next-generation sequencing for infection in hematology patients: a systematic review and meta-analysis

Variables

Subgroup

Number of studies

Sensitivity estimate (95% CI)

P value

Specificity estimate (95% CI)

P value

Research type

      
 

Retrospectively

11

0.89 (0.84–0.94)

0.27

0.47 (0.33–0.62)

0.01

 

Prospectively

5

0.81 (0.69–0.92)

 

0.82 (0.67–0.97)

 

Reference Standard

   

0.01

 

0.01

 

Clinical Diagnosis

11

0.85 (0.79–0.91)

 

0.70 (0.59–0.82)

 
 

CMT

5

0.91 (0.83–0.98)

 

0.32 (0.17–0.48)

 

Population

   

0.18

 

0.27

 

Adults

6

0.84 (0.73–0.95)

 

0.76 (0.65–0.88)

 
 

Children

5

0.85 (0.74–0.95)

 

0.51 (0.36–0.66)

 

Neutropeniaa

   

0.01

 

0.51

 

Yes

3

0.76 (0.58–0.93)

 

0.67 (0.35–1.00)

 
 

No

8

0.89 (0.83–0.94)

 

0.51 (0.30–0.73)

 

HSCTb

   

0.4

 

0.71

 

Yes

5

0.90 (0.82–0.97)

 

0.65 (0.42–0.88)

 
 

No

5

0.84 (0.74–0.93)

 

0.54 (0.33–0.76)

 
  1. P value is for the test for subgroup differences (random-effects model)
  2. CI confidence interval: CMT conventional microbiological tests
  3. aall patients are neutropenia
  4. ball patients are in hematopoietic stem cell transplant state