Table 2 Univariate cox and multivariate Cox proportional hazard regressions of 1-year overall-cause mortality among overall AD patients

In-ICU sepsis frequency

Single

Reference

Reference

Repeated

1.32 (1.03–1.70)

0.028

1.50 (1.16–1.93)

0.002

Age at admission, years

 < 65 years old

Reference

Reference

 ≥ 65 years old

1.79 (1.36–2.35)

< 0.001

1.27 (0.91–1.76)

0.161

Gender

 Male

Reference

 Female

1.15 (0.89–1.49)

0.281

Race

White

Reference

Black

1.17 (0.81–1.67)

0.398

Hispanic

1.55 (0.73–3.31)

0.254

Asian

0.60 (0.22–1.63)

0.320

Other

1.19 (0.70–2.03)

0.509

Unknown

1.26 (0.78–2.06)

0.344

Overlapping syndrome ^a

0.91 (0.56–1.49)

0.709

Length of ICU stay ^b

1.03 (1.02–1.05)

< 0.001

0.97 (0.95-1.00)

0.030

Comorbidities^a

Acute kidney injury

1.72 (1.33–2.21)

< 0.001

0.95 (0.71–1.27)

0.734

Chronic kidney disease

1.36 (1.05–1.75)

0.019

0.82 (0.60–1.12)

0.212

Atrial fibrillation

1.40 (1.09–1.81)

0.010

1.05 (0.79–1.39)

0.756

Essential hypertension

0.88 (0.67–1.15)

0.358

Myocardial infarction

1.31 (0.97–1.77)

0.076

Heart failure

1.51 (1.18–1.94)

0.001

0.94 (0.70–1.26)

0.675

Respiratory failure

1.97 (1.53–2.53)

< 0.001

1.46 (1.10–1.95)

0.009

COPD

1.59 (1.05–2.41)

0.028

1.13 (0.72–1.75)

0.601

Diabetes mellitus

1.05 (0.81–1.36)

0.727

HIV infection

0.86 (0.28–2.70)

0.802

Malignancy

1.92 (1.28–2.89)

0.002

1.23 (0.75–2.03)

0.417

Quantified assessment tools^b

Max SOFA

1.14 (1.11–1.17)

< 0.001

1.13 (1.08–1.18)

< 0.001

CCI

1.16 (1.11–1.21)

< 0.001

1.09 (1.02–1.17)

0.016

SAPS-II

1.05 (1.04–1.06)

< 0.001

1.02 (1.01–1.03)

< 0.001

Laboratory results^b

Max WBC count, K/𝜇L

1.00 (1.00-1.01)

0.087

Min Hb, g/dL

0.90 (0.83–0.98)

0.014

1.01 (0.93–1.10)

0.792

Min PLT, K/𝜇L

1.00 (1.00–1.00)

0.123

Drug therapies^a

Glucocorticoids

0.80 (0.49–1.31)

0.374

Immunosuppressants/biologics

0.60 (0.39–0.93)

0.023

0.55 (0.35–0.87)

0.011

IVIG

1.61 (0.85–3.03)

0.141