Table 5 A brief list of HTL Epitopes to form the final structure of the vaccine
specie | epitopes | protein | antigenicity | allergenicity | IFN-γ | IL4 | toxicity | epitope conservancy hit (maximum identity %) | human homology | interacting MHC-II alleles |
|---|---|---|---|---|---|---|---|---|---|---|
HPyV6 | VAAQRRVLMLESTRQ | LTAg | 0.8394 | probable non-allergen | positive | inducer | non-toxic | 100 | non-homologue | HLA-DRB1*04:10, HLA-DRB1*04:04, HLA-DRB1*04:05, HLA-DRB1*04:08 |
GLVNLVNYAVNYNRQ | VP2 | 0.7212 | probable non-allergen | positive | inducer | non-toxic | 100 | non-homologue | HLA-DRB1*08:06, HLA-DRB1*01:02, HLA-DRB1*08:13, HLA-DRB1*13:04, HLA-DRB1*08:01, HLA-DRB1*04:23 | |
GRFFRVHFRQRRVKH | VP1 | 0.4931 | probable non-allergen | positive | inducer | non-toxic | 100 | non-homologue | HLA-DRB1*11:20, HLA-DRB1*11:14, HLA-DRB1*13:23, HLA-DRB1*08:04, HLA-DRB5*01:01, HLA-DRB5*01:05 | |
SAGYIRAQGTPAGVE | VP1 | 0.8598 | probable non-allergen | positive | inducer | non-toxic | 100 | non-homologue | HLA-DRB1*09:01 | |
HPyV7 | DWNFVADFAADMELT | LTAg | 1.2109 | probable non-allergen | positive | inducer | non-toxic | 100 | non-homologue | HLA-DRB3*01:01, HLA-DRB1*03:09, HLA-DRB1*03:05, HLA-DRB1*04:21 |
FEPGGVVMYDTQNLP | VP2 | 0.9125 | probable non-allergen | negative | inducer | non-toxic | 100 | non-homologue | HLA-DRB1*15:06, HLA-DRB1*04:02, HLA-DRB1*08:06, HLA-DRB1*15:02, HLA-DRB1*08:04, HLA-DRB1*08:13, HLA-DRB1*04:10, HLA-DRB1*08:01 | |
FFRVHCRQRRIKHPY | VP1 | 0.4266 | probable non-allergen | negative | inducer | non-toxic | 100 | non-homologue | HLA-DRB5*01:05, HLA-DRB1*11:20, HLA-DRB1*11:14, HLA-DRB1*13:23 |