Table 4 A brief list of CTL Epitopes to form the final structure of the vaccine
specie | epitopes | protein | C-score | Immunogenicity score | antigenicity | allergenicity | toxicity | epitope conservancy hit (maximum identity %) | human homology | interacting MHC-I alleles |
|---|---|---|---|---|---|---|---|---|---|---|
HPyV6 | LSHATLGNK | LTAg | 1.2320 | 0.10205 | 1.5211 | probable non-allergen | non-toxic | 100 | non-homologue | HLA-A*11:01, HLA-A*03:01, HLA-A*30:01 |
FERWVSFGM | LTAg | 1.3474 | 0.24276 | 1.2787 | probable non-allergen | non-toxic | 100 | non-homologue | HLA-B*18:01, HLA-B*40:01, HLA-B*40:02 | |
WLLFVLEEL | VP2 | 1.1038 | 0.28696 | 0.7654 | probable non-allergen | non-toxic | 100 | non-homologue | HLA-A*02:01, HLA-A*02:06 | |
IYKVEAILL | VP1 | 1.5128 | 0.21171 | 0.4174 | probable non-allergen | non-toxic | 100 | non-homologue | HLA-A*24:02, HLA-B*35:03 | |
HPyV7 | MELTDVLLI | LTAg | 1.2565 | 0.08008 | 1.3253 | probable non-allergen | non-toxic | 100 | non-homologue | HLA-B*44:02, HLA-B*44:03, HLA-B*40:01, HLA-B*18:01, HLA-B*53:01, HLA-B*40:02, HLA-B*51:01 |
TPKRRNLLF | LTAg | 1.3998 | 0.01055 | 1.7138 | probable non-allergen | non-toxic | 100 | non-homologue | HLA-B*08:01, HLA-B*07:02 | |
GPRIGSTTM | VP2 | 0.08343 | 0.7918 | probable non-allergen | non-toxic | 100 | non-homologue | HLA-B*07:02 | ||
LWLPQAWPW | VP2 | 1.0974 | 0.08973 | 0.5232 | probable non-allergen | non-toxic | 100 | non-homologue | HLA-A*24:02, HLA-B*58:01, HLA-B*57:01, HLA-A*23:01, HLA-B*53:01 | |
DTMIVWEAY | VP1 | 2.0643 | 0.43299 | 0.5828 | probable non-allergen | non-toxic | 100 | non-homologue | HLA-A*26:01, HLA-A*25:01, HLA-A*01:01, HLA-B*35:01, HLA-B*18:01, HLA-A*29:02, HLA-A*30:02, HLA-B*46:01 | |
TELLFAPQM | VP1 | 1.0319 | 0.05903 | 0.8241 | probable non-allergen | non-toxic | 100 | non-homologue | HLA-B*18:01, HLA-B*44:02, HLA-B*40:02, HLA-B*44:03, HLA-B*40:01 |