Table 9 Biomarker “Consensus” and “All three biomarkers” performance comparisons Based on Criterion 1
Definitive UTI versus Definitive non-UTI | ||
|---|---|---|
≥ 10,000 Cells/mL and CFUs/mL | “Consensus”*** | “All three Biomarkers”*** |
Sensitivity (95% CI) | 84.0% (79.8%, 87.7%) | 66.1% (60.9%, 71.0%) |
Specificity (95% CI) | 91.2% (86.8%, 94.6%) | 97.4% (94.4%, 99.0%) |
Positive Predictive Value (95% CI) | 93.7% (90.4%, 96.1%) | 97.5% (94.6%, 99.1%) |
Negative Predictive Value (95% CI) | 78.8% (73.4%, 83.6%) | 65.1% (59.8%, 70.2%) |
Accuracy (95% CI) | 86.9% (83.8%, 89.5%) | 78.4% (74.8%, 81.7%) |
Positive Likelihood Ratio (95% CI) | 9.58 (6.29, 14.6) | 25.12 (11.36, 55.51) |
Negative Likelihood Ratio (95% CI) | 0.17 (0.11, 0.27) | 0.35 (0.16, 0.77) |