Table 6 Biomarker performance comparisons in the presence of microorganisms based on Criterion 1
Biomarker Performance Characteristics for Differentiating Definitive UTIs from Definitive non-UTIs | |||
|---|---|---|---|
≥ 10,000 Cells/mL and CFUs/mL | NGAL*** | IL-8*** | IL-1β*** |
Sensitivity (95% CI) | 82.6% (78.2%, 86.4%) | 91.2% (87.7%, 93.9%) | 69.8% (64.7%, 74.6%) |
Specificity (95% CI) | 90.8% (86.3%, 94.2%) | 76.8% (70.7%, 82.1%) | 96.9% (93.8%, 98.8%) |
Positive Predictive Value (95% CI) | 93.2% (89.9%, 95.8%) | 85.8% (81.8%, 89.2%) | 97.2% (94.4%, 98.9%) |
Negative Predictive Value (95% CI) | 77.2% (71.7%, 82.1%) | 85.0% (79.3%, 89.5%) | 67.6% (62.2%, 72.6%) |
Accuracy (95% CI) | 85.8% (82.7%, 88.6%) | 85.5% (82.4%, 88.3%) | 80.5% (77.0%, 83.6%) |
Positive Likelihood Ratio (95% CI) | 8.97 (5.95, 13.52) | 3.92 (3.09, 4.98) | 22.74 (10.93, 47.3) |
Negative Likelihood Ratio (95% CI) | 0.19 (0.13, 0.29) | 0.12 (0.09, 0.15) | 0.31 (0.15, 0.65) |