Table 1 Clinical characteristics of the enrolled 212 patients
Demographics | Infectious Group (n = 186) | Non-infectious Group (n = 28) | P value |
|---|---|---|---|
Male: Female | 1.63:1 (114:70) | 1.15:1 (15:13) | 0.39 |
Age (years) |  |  | < 0.01 |
Median | 55.5 (44–69) | 43 (28.5–57.5) |  |
Average (SD) | 55.2 ± 18.2 | 44.3 ± 17.8 |  |
Days from onset (days) | 15(10–22) | 12.5(8.5–17.5) | 0.07 |
Clinical Symptoms, n (%) | Â | Â | Â |
Fever | 160 (86.9%) | 26 (92.8%) | 0.37 |
Muscle or joint pain | 19 (10.3%) | 0 (0.0%) | 0.15 |
Abdomen pain with diarrhea | 13 (7.1%) | 1 (3.5%) | 0.08 |
Cough | 12 (6.5%) | 0 (0.0%) | 0.37 |
Headaches | 7 (3.8%) | 1 (3.5%) | 0.63 |
Vomiting | 2 (1.1%) | 0 (0.0%) | 1.00 |
Sample types of mNGS, N | Â | Â | Â |
Blood | 197 | 28 | Â |
CSF | 12 | Â | Â |
Ascitic fluid | 10 | 2 | Â |
Pleural effusion | 8 | 1 | Â |
Urine | 7 | Â | Â |
Sputum | 6 | Â | Â |
Pus | 5 | Â | Â |
BALF | 2 | Â | Â |
bone marrow | 2 | Â | Â |
Drainage and Puncture fluid | 12 | Â | Â |
Puncture | 2 | 1 | Â |
Blood routine examination | Â | Â | Â |
Whole blood cell (×109/L) | 7.2 (5.1–11.1) | 6.4 (4.5–10.2) | 0.56 |
Neutrophils % | 73.5 (60.4–84.2) | 68.1 (59.4–77.2) | 0.08 |
Lymphocytes % | 17.6 (8.8–26.0) | 18.45 (12.7–27.3) | 0.56 |
Immune status | Â | Â | 0.96 |
Normal | 174 | 27 | Â |
Immunocompromised | 10 | 1 | Â |
Examination findings | Â | Â | Â |
C-reactive protein (mg/L), median (IQR) | 62.3 (14.3-124.9) | 40.0 (12.1–74.2) | 0.34 |
Procalcitonin (µg/L), median (IQR) | 0.18 (0.08–0.77) | 0.12 (0.07–0.57) | 0.02 |