Fig. 2

The diagnostic efficiency and performance of mNGS in identifying infectious and non-infectious disease. (A) The diagnostic efficiency by mNGS and conventional methods based on the clinical diagnosis. (B) Infection types of the enrolled cases based on final clinical diagnosis. (C) The comparison of detection rate and total coincidence rate (TCR) between BSI and non-BSI group. (D) The performance of mNGS in identifying infectious and non-infectious fever. Abbreviations: PPV, positive predictive value; NPV, negative predictive value; TCR, total coincidence rate; BSI, bloodstream infection; LRTI, lower respiratory tract infection; IAI, intra-abdominal infection; SSTI, skin or soft-tissue infection; CNSI, central nervous system infection; UTI, urinary tract infection; sin-sub, single sample subgroup; multi-sub, multiple samples subgroup