Table 6 Performance characteristics of POCTs for CT compared to reference assays (meta-analysis data)

4001—Italy

299

100 (47.82–100)

100 (98.75–100)

100 (82.35–100)

98.53 (96.28–99.60)

83.33 (35.88–99.58)

98.98 (97.04–99.79)

4005—Malta

742

57.89 (33.50–79.75)

99.86 (99.22–100)

74.42 (63.87–83.22)

99.22 (98.20–99.75)

96.15 (80.36–99.90)

99.85 (99.19–100)

4006—Peru1

267

81.82 (48.22–97.72)

100 (98.56–100)

78.13 (60.03–90.72)

99.10 (96.77–99.89)

75.00 (47.62–92.73)

99.60 (97.79–99.99)

4007—Peru2

394

40.00 (12.16–73.76)

99.74 (98.54–99.99)

76.00 (61.83–86.94)

99.71 (98.38–99.99)

66.67 (22.28–95.67)

99.74 (98.56–99.99)

Fixed effects model

64.44 (46.92–78.80)

99.88 (99.38–99.98)

78.07 (70.32–84.26)

99.19 (98.43–99.58)

85.19 (70.39–93.29)

99.63 (99.05–99.85)

Random effects model

67.79 (42.92–85.49)

99.88 (99.51–99.97)

78.07 (71.57–83.44)

99.19 (98.58–99.54)

84.82 (67.76–93.69)

99.63 (99.14–99.84)

Between sites variability—SD (p-value)

Between sites variability—SD (p-value)

Between sites variability—SD (p-value)

7.74 (0.64)

-

-

-

7.61 (0.60)

7.14 (0.94)

DOR

1720.83 (305.54–9691.86)

DOR

435.33 (223.61–847.51)

DOR

1500.57 (412.30–5461.33)

LR + 

554.89 (133.34–2309.09)

LR + 

96.23 (54.46–170.03)

LR + 

228.68 (97.31–537.39)

LR-

0.32 (0.16–0.65)

LR-

0.22 (0.17–0.29)

LR-

0.15 (0.07–0.35)