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Table 4 Clinical response and associated adverse events

From: A regimen based on the combination of trimethoprim/sulfamethoxazole with caspofungin and corticosteroids as a first-line therapy for patients with severe non-HIV-related pneumocystis jirovecii pneumonia: a retrospective study in a tertiary hospital

 

Total, n = 38

ST group, n = 20

MT group, n = 18

P

Positive of clinical response [%, no.]

84.21(32/38)

100.00(20/20)

66.70(12/18)

0.026*

Duration of hospital stay

20.50(10.75–31.25)

30.00(10.50–42.50)

15.00(9.00-22.25)

0.059

Duration of fever

8.00(6.00-10.25)

7.00(5.00-8.75)

11.50(8.00-16.25)

0.029*

Dose of TMP, mg/kg/day

16.55(15.69–18.67)

15.71(14.23–16.43)

18.35(16.48–19.40)

0.001*

All-cause mortality,%

21.05(8/38)

25.00(5/20)

16.67(3/18)

0.277

All adverse effects [%, no.]

31.58(12/38)

15.00(3/20)

50.00(9/18)

0.022*

Nausea/Vomiting [%, no.]

10.53(4/38)

5.00(1/20)

16.67(3/18)

 

Hyperkaliemia [%, no.]

7.89(3/38)

5.00(1/20)

11.11(2/18)

 

Diarrhea [%, no.]

7.89(3/38)

0.00(0/20)

16.67(3/18)

 

Thrombocytopenia [%, no.]

2.63(1/38)

5.00(1/20)

0.00(0/18)

 

Drug eruption [%, no.]

2.63(1/38)

0.00(0/20)

5.56(1/18)

 
  1. ST group, synergic therapy group; MT group, monotherapy group;