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Table 1 Sociodemographic characteristics of patients

From: A regimen based on the combination of trimethoprim/sulfamethoxazole with caspofungin and corticosteroids as a first-line therapy for patients with severe non-HIV-related pneumocystis jirovecii pneumonia: a retrospective study in a tertiary hospital

Parameters

Total

ST group

MT group

P

No. of patients

38

20

18

 

Age, yr [median (IQR)]

59.50(37.75-62.00)

54.00(40.25-62)

46.00(36.50-56.75)

0.273

Gender, male/female

25/13

13/7

12/6

0.915

Bodyweight, kg, [median (IQR)]

61.00(55.00-67.25)

62.00(55.00-68.75)

59.50(55.75–65.5)

0.568

PaO2/FiO2

199.85(114.44-238.89)

181.75(83.63-225.88)

224.35(163.75-240.11)

0.066

Scores

    

 APACHE II score, [median (IQR)]

19.00 (13.00-25.25)

19.00(17.00-25.75)

19.50(9.00-25.50)

0.235

 SOFA score, [median (IQR)]

7.00(5.00-9.25)

7.00(6.00–10.00)

6.00(2.00–8.00)

0.086

 Vasopressor utilization ratio,[%. no.]

37.10 (13/35)

45.00(9/20)

27.80(5/13)

0.278

CRRT utilization ratio, [%. no.]

40.00(14/35)

40.00(8/20)

44.40(8/10)

0.785

Lab test

    

 Albumin, g/L

27.20(23.55–31.60)

28.05(24.52–31.83)

24.75(21.68–28.95)

0.111

 LDH, U/L, [median (IQR)]

600.50(367.25–725.00)

629.50(391.50-807.25)

512.50(326.25–725.00)

0.492

 C-reactive protein, mg/L, [median (IQR)]

64.68(33.95-135.28)

71.70(54.60-162.73)

49.70(22.15–91.05)

0.068

 Interleukin-6, pg/mL, [median (IQR)]

77.74(23.40-311.53)

59.88(22.74-359.98)

112.15(28.65-309.83)

0.792

 Procalcitonin, ng/mL, [median (IQR)]6

1.13(0.44–3.43)

1.15(0.48–5.69)

0.81(0.32–2.01)

0.306

 CD4 count, cells/µL, [median (IQR)]

124.50 (85.21-171.75)

98.99(68.50-148.75)

142.50(113.00-184.25)

0.059

 Serum β-(1,3)-D-glucan, pg/mL, [median (IQR)]

197.14(120.34-271.53)

207.7(121.95-319.79)

184.42(111.60-267.78)

0.693

Total Other pathogen dectected, [%. no.]

68.42(26/38)

75.00(15/20)

61.11(11/18)

0.364

 Bacteria

36.84(14/38)

40.00(8/20)

33.33(6/18)

 

 Virus

34.21(13/38)

45.00(9/20)

22.22(4/18)

 

 Fungus

5.26(2/38)

5.00(1/20)

5.56(1/18)

 
  1. ST group, synergic therapy group; MT group, monotherapy group; APACHE II score, acute Physiology and Chronic Health Evaluation II score; SOFA score, sepsis related Organ Failure Assessment score; CRRT, continuous renal replacement therapy; LDH, lactate dehydrogenase; PEEP, positive end expiratory pressure; Vt, tidal volume; PBW, predicted body weight