Table 1 Demographic characteristics, comorbid conditions, clinical representations, laboratory parameters of patients with SFTS between the survivor and non-survivor groups

Male, n (%)

128(53.3)

19(38.0)

0.049

Age (years)

64 ± 7

66 ± 8

0.048

Diabetes, n (%)

16(6.7)

7(14.0)

0.081

Hypertension, n (%)

56(23.3)

15(30.0)

0.319

Bacterial or fungal infections, n (%)

126(52.5)

49(98.0)

< 0.001

Days from onset to admission

6(5–8)

7(5–9)

0.548

Clinical manifestations, n (%)

 Neurological

  Headache

43(17.9)

12(24.0)

0.318

  Dizziness

76(31.7)

19(38.0)

0.385

  Encephalopathy

21(8.8)

24(48.0)

< 0.001

 Respiratory

  Cough

54(22.5)

13(26.0)

0.495

  Sputum

41(17.1)

18(36.0)

0.003

  Chest distress

46(19.2)

13(26.0)

0.275

 Gastrointestinal

  Anorexia

174(72.5)

38(76.0)

0.612

  Nausea

158(65.8)

34(68.0)

0.768

  Vomiting

77(32.1)

14(28.0)

0.571

  Abdominal pain

25(10.4)

23(46.0)

< 0.001

  Diarrhea

56(23.3)

14(28.0)

0.483

 SIRS

91(37.9)

35(70.0)

< 0.001

 ARDS

6(2.5)

14(28.0)

< 0.001

 AKI

35(14.6)

32(64.0)

< 0.001

 Shock

8(3.3)

17(34.0)

< 0.001

Laboratory parameters

 WBC (10⁹/L)

3.6(2.0-6.6)

3.7(2.7–6.4)

0.671

 Neutrophils (10⁹ /L)

2.1(1.1–4.8)

2.9(1.3–4.9)

0.413

 Neutrophils (%)

68.6(52.1–82.0)

71.0(59.0-82.8)

0.492

 Lymphocyte (10⁹/L)

0.7(0.5–1.1)

0.6(0.4–1.4)

0.689

 Lymphocyte (%)

22.0(11.7–33.7)

21.8(13.5–28.3)

0.484

 Platelet (10⁹ /L)

43(31–63)

34(21–56)

0.002

 Hemoglobin (g/L)

125 ± 20

119 ± 21

0.211

 ALT (U/L)

63(44–108)

138(74–271)

< 0.001

 AST (U/L)

143(69–292)

596(282–1151)

< 0.001

 TBIL(μmol/L)

11.7(8.7–17.2)

13.8(9.6–22.1)

0.089

 Albumin (g/L)

30.3 ± 5.8

27.7 ± 4.2

< 0.001

 Globulin (g/L)

25.9(23.4–29.4)

25.8(22.3–30.4)

0.881

 ALP (U/L)

71(55–93)

109(73–194)

< 0.001

 GGT (U/L)

35(21–82)

90(34–210)

< 0.001

 LDH (U/L)

572(337–861)

1000(896–2036)

< 0.001

 Amylase (U/L)

142(94–204)

242(146–339)

< 0.001

 Lipase (U/L)

149(79–272)

318(172–536)

< 0.001

 BUN (mmol/L)

5.2(3.7–6.8)

7.3(5.2–13.0)

< 0.001

 Creatinine (μmol/L)

71(61–91)

175(69–274)

< 0.001

 Cystatin-C (mg/L)

1.2(0.9–1.5)

1.4(1.1–2.7)

< 0.001

 Sodium (mmol/L)

135.3(132.0-138.0)

134.2(130.5-138.4)

0.468

 Potassium (mmol/L)

3.5(3.3-4.0)

3.9(3.5–4.5)

< 0.001

 CK (U/L)

259(97–804)

969(467–1942)

< 0.001

 CK-MB (U/L)

25(14–41)

77(40–129)

< 0.001

 Troponin I (pg/mL)

80.2(35.4-177.6)

233.5(101.6–407.0)

< 0.001

 BNP (pg/mL)

60(22–158)

125(58–369)

0.001

 PT (s)

11.3(10.6–12.0)

11.7(11.1–12.8)

0.003

 INR

1.03(0.97–1.10)

1.07(1.01–1.18)

0.002

 PTA (%)

99(88–111)

95(80–105)

0.038

 APTT(s)

39.3(33.7–44.7)

52.7(44.1–63.1)

< 0.001

 TT(s)

17.3(15.9–19.6)

22.4(19.2–28.5)

< 0.001

 Fibrinogen (mg/dL)

256(206–300)

205(147–238)

< 0.001

 D-dimer (ng/mL)

900(403–1992)

1862(826–3469)

< 0.001

 CRP (mg/L)

6.9(3.0-13.2)

19.9(9.9–30.0)

< 0.001

 Procalcitonin (ng/mL)

0.16(0.06–0.49)

0.91(0.27–1.96)

< 0.001

 IL-6 (pg/mL)

21.9(14.2–36.5)

63.2(42.6-158.9)

< 0.001

 SAA (mg/L)

33.5(22.5–71.4)

243.7(55.7-277.4)

< 0.001

 ESR (mm/h)

8(5–14)

14(7–21)

0.003

 Ferritin (ng/mL)

2947(2261–4435)

9371(4166–20,419)

< 0.001

 Viral load (log₁₀ copies/mL)

3.8(3.3–4.3)

5.4(4.4–6.1)

< 0.001