Time to sputum culture conversion and its associated factors among drug-resistant tuberculosis patients: a systematic review and meta-analysis

Table 4 Meta analysis of the factors affecting the sputum culture conversion time among DR-TB patients

The influence factors were included	Exposure factors	Number of articles included	Heterogeneity			aHR	95%CI	P
The influence factors were included	Exposure factors	Number of articles included	I² (%)	P	effects model	aHR	95%CI	P
Sex	Male	4	0	0.57	Fixed	0.99	0.91 ~ 1.07	0.80
Sex	Female	3	0	0.84	Fixed	0.59	0.46 ~ 0.76	< 0.0001
Alcohol	Alcohol history	3	49	0.14	Fixed	0.70	0.50 ~ 0.98	0.039
Smoking status	Smoking history	3	0	0.506	Fixed	0.58	0.38 ~ 0.88	0.01
Smoking status	Current smoker	2	79.2	0.028	Random	0.61	0.30 ~ 1.24	0.17
TB treatment history		3	0	0.925	Fixed	0.94	0.83 ~ 1.09	0.46
History of SLD use		2	0	0.96	Fixed	0.64	0.47 ~ 0.87	0.004
BMI	BMI < 18.5 kg/m²	4	0	0.89	Fixed	0.69	0.60 ~ 0.80	< 0.0001
Diabetes		4	79.1	0.002	Random	0.77	0.50 ~ 1.17	0.22
lung cavity		5	70.3	0.009	Random	0.70	0.52 ~ 0.94	0.016
HIV		2	0	0.673	Fixed	0.76	0.42 ~ 1.21	0.36
Sputum smear grading	Positive	3	50.3	0.13	Random	0.56	0.36 ~ 0.87	0.009
	grade 1 +	3	0	0.94	Fixed	0.87	0.77 ~ 0.99	0.043
	grade 2 +	3	0	0.66	Fixed	0.81	0.69 ~ 0.95	0.009
	grade 3 +	3	0	0.94	Fixed	0.71	0.61 ~ 0.84	< 0.0001
Resistance to ofloxacin		3	58.6	0.09	Random	0.67	0.43 ~ 1.04	0.07
Resistance to all five first lines drugs		2	0	0.973	Fixed	0.86	0.62 ~ 1.21	0.395

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