Skip to main content

Table 2 Baseline of included studies, NA: Not available

From: The diagnostic utility of heparin-binding protein among patients with bacterial infections: a systematic review and meta-analysis

Study ID

Study groups

Sample size

Age Mean (SD)

Gender (Male) n (total)

HBP at baseline Mean (SD)

Comorbidities

n (%)

Kjolvmark 2012 [13]

Group 1

78

6.5 (5.04)

1 (10)

203 (187)

NA

Group 2

7.7 (4.6)

1 (5)

113 (65)

NA

Group 3

2 (4.25)

7 (30)

5 (29.5)

NA

Group 4

7 (4.5)

17 (33)

4 (18.5)

NA

Kjolvmark 2014 [12]

Definite Cystitis PC

390

58 (54.81)

6 (105)

141.66 (149.62)

NA

Definite Pyelonephritis PC

51.33 (49.62)

0 (12)

345.66 (322.96)

NA

Probable Cystitis

54.33 (51.85)

1 (29)

98 (104.44)

NA

Probable Pyelonephritis PC

71 (NA)

0 (1)

386 (NA)

NA

No UTI PC

54.66 (51.11)

11 (47)

6.66 (6.66)

NA

Controls

57.33 (17.77)

4 (25)

10 (11.11)

NA

Definite Cystitis H

56 (62.29)

2 (13)

203.66 (308.97)

NA

Definite Pyelonephritis H

59 (56.59)

26 (47)

236.33 (258.48)

NA

Probable Cystitis H

51.33 (62.78)

3 (10)

92 (139.18)

NA

Probable Pyelonephritis H

56.33 (55.3)

2 (5)

279.33 (681.81)

NA

No UTI H

59 (55.7)

51 (96)

7.66 (6.77)

NA

Kjolvmark 2016 [28]

Asymptomatic bacteriuria

163

87.66 (5.39)

4 (38)

102.33 (151.77)

Urogenital disease 5 (13) , Malignancy 9 (24) , Diabetes mellitus 4 (11), Chronic obstructive disease 4 (11)

Urinary tract infection

87 (7.63)

20 (49)

257.33 (3.11)

 

Indwelling catheter

87.33 (8.044)

15 (18)

412 (320.98)

Urogenital disease 9 (50), Malignancy 6 (33), Diabetes mellitus 6 (33), Chronic obstructive disease 1 (6)

Negative culture

87 (8.36)

15 (57)

11.33 (17.49)

Urogenital disease 5 (9), Malignancy 7 (12), Diabetes mellitus 8 (14), Chronic obstructive disease 3 (5)

Kong 2022 [24]

Infected group

323

49 (44.97)

64 (131)

Culture-positive group 162.66

Culture-negative group 132.66 (culture-positive group 72.66 culture negative group 80.53)

Cardiovascular disease: 33 (25), Respiratory disease 6 (5), Endocrine disease 12 (9), Central nervous system disease 29 (22), Digestive system disease 8 (6), No medical history 43 (33)

Control group

49 (41.9)

62 (151)

NA

Cardiovascular disease: 39 (26), Respiratory disease 3 (2), Endocrine disease 10 (7%), Central nervous system disease 34 (23), Digestive system disease 12 (8), No medical history 48 (32)

Linder 2011 [25]

Bacterial Meningitis

174

51 (16)

20 (41)

415.33 (649.93)

21 (41.1)

Viral Encephalitis

55 (13)

10 (19)

16.33 (30.43)

4 (19)

Viral Meningitis

43 (17)

6 (10)

15.76 (31.73)

1 (10)

Neuroborreliosis

53 (16)

3 (7)

5.6 (6.2)

2 (6.7)

Namiduru 2022 [11]

Bacterial meningitis

97

40.19 (2.73)

18 (37)

Serum HBP 14.98 – CSF HBP 7.81 (Serum HBP 1.1 - CSF HBP 0.2)

NA

Tuberculosis meningitis

42.6 (3.31)

17 (30)

Serum HBP 6.89 - CSF HBP 6,11 (Serum HBP 0.4 - CSF HBP 0.3)

NA

Viral meningitis

45.4 (2.56)

19 (30)

Serum HBP 6.02 - CSF HBP 5.75 (Serum HBP 0.4 - CSF HBP 0.1)

NA

Obreja 2022 [10]

Bacterial Meningitis

81

52.72 (20.03)

29 (47)

HBP in CSF 66.00 HBP in blood: 4.86 (HBP in CSF 134.50 HBP in blood: 6.71)

Alcoholism 21 (44.7) Smoking 7 (14.9)

Viral Meningitis

57.2 (16.6)

22 (34)

HBP in CSF 2.38 HBP in blood: 18.88 (HBP in CSF 5.63 HBP in blood: 58.13)

Alcoholism 12 (35.3) Smoking 9 (26.5)

Zhang 2019 [27]

BII

134

35.9 (16.8)

23 (40)

88.1 (38.2)

NA

NBII

36.9 (17.6)

31 (54)

30.1 (14.6)

NA

Control

36.2 (17.2)

19 (40)

23.56 (11.2)

NA

Kandil 2018 [21]

Bacterial group

90

24.7 (14.7)

19 (30)

192.2 (56.6)

NA

Viral group

24.7 (14.8)

18 (30)

3.7 (1.9)

NA

Control group

24.9 (14.3)

12 (30)

0.84 (0.3)

NA

Yang 2022 [23]

Research group (bacterial & viral infection groups)

195

≥5 years: 62(47.69)

<5 years: 68 (52.31)

81 (130)

Bacterial group: 31.58 (5.03). Viral: 25.21 (2.73)

NA

Control group

≥5 years: 32 (49.23)

<5 years: 33 (50.77)

37 (65)

3.23 (0.82)

NA

Niu 2019 [22]

Bacterial group

497

NA

NA

62.1 (57.2)

NA

Viral group

NA

NA

9 (3.5)

NA

Sepsis

NA

NA

92.8 (37.6)

NA

Tumor

NA

NA

13.9 (10.6)

NA

Cardiovascular Diseases

NA

NA

27 (35.6)

NA

Ren 2021 [26]

Purulent Meningitis

308

3.6 (0.4)

60 (118)

NA

NA

Viral Meningitis

 

3.7 (0.5)

63 (110)

NA

NA

Control group

 

3.2 (0.6)

41 (80)

NA

NA

Chalupa 2011 [20]

Bacterial Infections group

81

46.8 (18.2)

27 (54)

51 (31.9891)

NA

Viral infections group

42.8 (15.2)

18 (27)

21 (7.0441)

NA

Lertdumrongluk 2015 [29]

APN

32

1.6 (1.075)

12 (17)

NA

NA

Control group

4.55 (2.96)

9 (15)

NA

NA

Cai 2021 [19]

Bacterial group

102

69.93 (17.28)

71(108)

53.653 (33.79)

NA

Fungal group

67.76 (17.78)

12 (21)

62.47 (93.409)

NA

Viral group

64.79 (21.1)

19 (33)

11.727 (6.285)

NA