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Table 1 Critical care admission, and clinical/laboratory parameters during the first 24 h

From: A retrospective analysis of 20,178 adult neurological infection admissions to United Kingdom critical care units from 2001 to 2020

Characteristic

Summary

Patients with data

Median (IQR) or N(%)

Age (years)

20,176

53 (37, 66)

Sex

20,178

 

- Male

 

11,086 (54.9%)

- Female

 

9092 (45.1%)

Body mass index

14,136

25.7 (22.9, 29.4)

Type of admission

20,178

 

- Encephalitis

 

6725 (33.3%)

- Meningitis, unspecified

 

5360 (26.6%)

- Bacterial meningitis, non-meningococcal

 

3105 (15.4%)

- Intracranial abscess

 

2730 (13.5%)

- Meningococcal meningitis

 

1096 (5.4%)

- Infected CSF shunt

 

665 (3.3%)

- Viral meningitis

 

363 (1.8%)

- Tuberculous meningitis

 

132 (0.7%)

Time from hospital admission to critical care unit admission (days)

20,177

0 (0, 1)

Location prior to critical care unit admission *

16,464

 

- Accident and emergency

 

6961 (42.3%)

- Hospital ward

 

5225 (31.7%)

- Theatre or recovery

 

1801 (10.9%)

- Level 3 ICU

 

1280 (7.8%)

- Recovery as temporary critical care

 

308 (1.9%)

- HDU equivalent bed

 

233 (1.4%)

- Level 2 HDU

 

226 (1.4%)

- Imaging department

 

199 (1.2%)

- Enhanced care (non-HDU/ICU)

 

139 (0.8%)

- Obstetrics

 

35 (0.2%)

- Not in the hospital

 

31 (0.2%)

- Outpatients

 

1 (0%)

- Paediatrics

 

1 (0%)

Past medical history *

19,965

 

- Chemotherapy

 

410 (2.1%)

- Steroid treatment

 

308 (1.5%)

- Chronic renal replacement therapy

 

288 (1.4%)

- HIV

 

279 (1.4%)

- Metastatic disease

 

172 (0.9%)

- Radiotherapy

 

158 (0.8%)

- Lymphoma

 

148 (0.7%)

- Severe respiratory disease

 

106 (0.5%)

- Biopsy proven cirrhosis

 

100 (0.5%)

- AML or ALL or multiple myeloma

 

93 (0.5%)

- Hepatic encephalopathy

 

86 (0.4%)

- CML or CLL

 

81 (0.4%)

- Very severe cardiovascular disease

 

77 (0.4%)

- Congenital immuno-humoral or cellular immune deficiency state

 

48 (0.2%)

- Home ventilation

 

20 (0.1%)

Baseline observations #

  

- Lowest temperature (oC)

20,021

36.1 (35.6, 36.6)

- Highest temperature (oC)

19,769

37.7 (37.0, 38.4)

- Lowest blood pressure (mmHg)

20,062

97 (86, 109)

- Highest blood pressure (mmHg)

20,019

155 (140, 174)

- Lowest heart rate (bpm)

20,059

68 (57, 80)

- Highest heart rate (bpm)

20,008

105 (90, 120)

- Lowest non-ventilated respiratory rate (breaths per min)

11,549

14 (12, 18)

- Lowest ventilated respiratory rate (breaths per min)

13,439

12 (12, 15)

- Highest ventilated respiratory rate (breaths per min)

12,116

18 (15, 23)

Arterial blood gas – lowest pO2

  

- pO2 (KPa)

17,734

10.7 (9.2, 12.5)

- FiO2

17,721

0.30 (0.25, 0.40)

- PaCO2 (KPa)

17,732

4.9 (4.4, 5.6)

- pH (KPa)

17,726

7.41 (7.36, 7.45)

Arterial blood gas – lowest pH

  

- PaCO2 (KPa)

17,480

5.5 (4.8, 6.3)

- pH

17,479

7.36 (7.30, 7.40)

Baseline blood tests #

  

- Lowest serum bicarbonate (mmol/l)

7891

22.0 (19.4, 24.5)

- Highest serum bicarbonate (mmol/l)

6116

24.7 (22.4, 27.0)

- Lowest serum sodium (mmol/l)

19,479

137 (134, 140)

- Highest serum sodium (mmol/l)

15,351

141 (138, 144)

- Lowest serum potassium (mmol/l)

19,421

3.7 (3.3, 4.0)

- Highest serum potassium (mmol/l)

15,405

4.3 (4.0, 4.6)

- Lowest serum creatinine (µmol/l)

19,327

69 (53, 94)

- Highest serum creatinine (µmol/l)

13,770

80 (62, 116)

- Lowest serum glucose (mmol/l)

16,287

6.1 (5.1, 7.4)

- Highest serum glucose (mmol/l)

14,321

9.2 (7.4, 11.6)

- Highest blood lactate (mmol/l)

14,183

1.6 (1.1, 2.6)

- Highest serum urea (mmol/l)

19,039

6.0 (4.2, 9.0)

- Lowest white blood cell count (x109/L)

19,320

11.7 (8.1, 17.0)

- Highest white blood cell count (x109/L)

13,641

15.1 (10.5, 21.3)

- Lowest platelet count (x109/L)

19,071

199 (140, 270)

Urine output (mls)

19,692

1984 (1292, 2920)

Glasgow coma score (/15)

12,035

10 (7, 14)

Pupil reactivity

13,999

 

- Left pupil reactive to light

 

12975 (93.7%)

- Right pupil reactive to light

 

12952 (93.6%)

Sedated and ventilated

20,108

 

- Sedated for all of first 24 hours

 

7073 (35.2%)

- Paralysed and sedated for all of first 24 hours

 

451 (2.2%)

- Paralysed and sedated for some of first 24 hours

 

5865 (35.2%)

- Not sedated and ventilated

 

6719 (35.2%)

  1. N = number of patients for whom data are available, included in that statistic. Summary statistic = the median (1st and 3rd quartile) value for continuous data, and the number and frequency (%) of patients with the characteristic for categorical data. Age is defined as age of admission to critical care unit, derived from date of birth and date of admission to critical care unit. Body mass index is derived from weight and height data (kg/m2). *For location prior to critical care unit admission, and past medical history, individual options are listed as defined as per ICNARC data collection manual 3.1 (2013). #Lowest and highest admission parameters (baseline observations and baseline blood tests), as selected by ICNARC [22], are defined as lowest and highest values during the first 24 h of critical care unit admission, respectively. ‘Temperature’ represents central temperature. ‘Lowest blood pressure’ represents lowest systolic blood pressure with paired diastolic reading. ‘Highest blood pressure’ represents highest systolic blood pressure with paired diastolic reading. ALL = acute lymphocytic leukaemia. AML = acute myeloid leukaemia. bpm = beats per minute. CLL = chronic lymphocytic leukaemia. CSF = cerebrospinal fluid. HDU = high dependency unit. HIV = Human immunodeficieny virus. ICNARC = Intensive Care National Audit and Research Centre. ICU = intensive care unit. Min = minute
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BMC Infectious Diseases

ISSN: 1471-2334

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