Fig. 4

Genome-wide expression deconvolution of parasite RNAseq data. A Principal component analysis (PCA) of parasite RNA-seq data from paired asymptomatic and febrile malaria normalized for library size, parasite blood stage development and 3 factors of unwanted variation (normalized counts available in (Additional file 1: Table S2). The samples are colored by the clinical phenotype, blue for asymptomatic infections and red for febrile malaria. Ellipses represent 95% confidence intervals. B Scatter plot showing the correlation between the parasite density (log10) and the estimated proportions of non-ring stages across all the samples. The samples are colored by the clinical phenotype, blue for asymptomatic infections and red for febrile malaria