Fig. 3

Asymptomatic infections are characterized by older, non-ring parasites compared to ensuing febrile malaria. A Dot plot showing the maximum likelihood estimation (MLE) of the hours post-invasion (hpi) determined using reference dataset from Bozdech et al. 2003. The samples are colored by clinical phenotype, asymptomatic infections (blue) and febrile malaria (red). The black dot shows the median hpi. B Boxplots showing the estimated proportions of parasite blood stage development in asymptomatic infections and febrile malaria as estimated using a mixture model and reference dataset from López-Barragán et al. (2011). For each parasite stage, Wilcoxon test (corrected for multiple testing using Benjamini & Hochberg) was performed to evaluate the difference in the proportions of parasites between asymptomatic and febrile malaria. The samples are colored by clinical phenotype, blue for asymptomatic infections and red for febrile malaria