Table 5 Comparison of interventions between survival group and death group in patients with CAPA
Variables | Survival group (n = 95) | Death group (n = 73) | P |
|---|---|---|---|
ICU admission, n (%) | 25 (26.3) | 67 (91.8) | < 0.001 |
ICU length of hospitalization, days | 14 (8 ~ 37) | 10 (6 ~ 16.5) | 0.012 |
Total length of hospital stays, day | 23 (15.0 ~ 35.5) | 17 (10 ~ 28) | 0.001 |
Number of antibiotics, n | 2 (2 ~ 4) | 4 (3 ~ 5) | < 0.001 |
Meropenem, n (%) | 36 (37.9) | 43 (58.9) | 0.008 |
Vancomycin, n (%) | 8 (8.4) | 15 (20.6) | 0.040 |
Teicoplanin, n (%) | 15 (15.8) | 22 (30.1) | 0.038 |
Imipenem, n (%) | 21 (22.1) | 43 (58.9) | < 0.001 |
Etimicin, n (%) | 9 (9.5) | 3 (4.1) | 0.234 |
Fluoroquinolones, n (%) | 62 (65.3) | 43 (58.9) | 0.425 |
Polymyxin B, n (%) | 7 (7.4) | 23 (31.5) | < 0.001 |
Linezolid, n (%) | 4 (4.2) | 20 (27.4) | < 0.001 |
Cephalosporin, n (%) | 73 (76.8) | 59 (80.8) | 0.574 |
Tigecycline, n (%) | 2 (2.1) | 4 (5.5) | 0.405 |
Duration of antibiotic therapy, days | 20 (13 ~ 29.5) | 17 (9 ~ 26) | 0.083 |
Ganciclovir, n (%) | 5 (5.3) | 7 (9.6) | 0.368 |
Ribavirin, n (%) | 0 (0) | 0 (0) | - |
Amubarvimab, n (%) | 6 (6.3) | 4 (5.5) | 1.000 |
Tocilizumab, n (%) | 8 (8.4) | 5 (6.9) | 0.778 |
Antiviral therapy#, n (%) | 50 (52.6) | 42 (57.5) | 0.537 |
Traditional Chinese Medicine, n (%) | 16 (16.8) | 25 (34.2) | 0.011 |
Immunoglobulin, n (%) | 47 (49.5) | 55 (75.3) | < 0.001 |
Thymosin, n (%) | 13 (13.7) | 6 (8.2) | 0.330 |
Glucocorticoid, n (%) | 70 (73.7) | 65 (89.0) | 0.018 |
Duration of glucocorticoid therapy, days | 10 (6.3 ~ 16.8) | 9 (6 ~ 16) | 0.663 |
Cumulative glucocorticoid dose *, mg | 1800 (1276 ~ 3037.5) | 2600 (1500 ~ 4000) | 0.027 |
Oxygen therapy, n (%) | 83 (87.4) | 73 (100) | 0.001 |
High-flow oxygen therapy, n (%) | 30 (31.6) | 47 (64.4) | < 0.001 |
Non-invasive mechanical ventilation, n (%) | 7 (7.4) | 11 (15.1) | 0.134 |
Invasive mechanical ventilation, n (%) | 12 (12.6) | 60 (82.2) | < 0.001 |
ECMO, n (%) | 1 (1.1) | 9 (12.3) | 0.003 |
Invasive operation, n (%) | 62 (65.3) | 73 (100) | < 0.001 |
Indwelling urinary catheterization, n (%) | 37 (39.0) | 66 (90.4) | < 0.001 |
Central venous catheterization, n (%) | 42 (44.2) | 69 (94.5) | < 0.001 |
Puncture and drainage, n (%) | 15 (15.8) | 9 (12.3) | 0.658 |
Tracheal intubation, n (%) | 11 (11.6) | 59 (80.8) | < 0.001 |
Tracheotomy, n (%) | 5 (5.3) | 22 (30.1) | < 0.001 |
Fiberoptic bronchoscopy, n (%) | 22 (23.1) | 37 (50.7) | < 0.001 |
CRRT, n (%) | 3 (3.2) | 28 (38.4) | < 0.001 |
Artificial liver treatment, n (%) | 1 (1.1) | 0 (0) | 1.000 |