Table 2 Comparison of interventions between the CAPA group and non-fungal infection group

ICU admission, n (%)

85 (50.6)

22 (13.1)

< 0.001

ICU length of hospitalization, days

2 (1 ~ 7)

6.0 (3.0 ~ 8.5)

0.006

Mortality, n

73 (43.5)

17 (10.1)

< 0.001

The length of hospital stays, days

9 (6 ~ 14)

9 (7 ~ 16)

0.179

Number of antibiotics, n

3 (2 ~ 4)

1 (1 ~ 2)

< 0.001

Meropenem, n (%)

52 (31.0)

21 (12.5)

< 0.001

Vancomycin, n (%)

15 (8.9)

4 (2.4)

0.016

Teicoplanin, n (%)

21 (12.5)

9 (5.4)

0.034

Imipenem, n (%)

45 (26.8)

17 (10.1)

< 0.001

Etimicin, n (%)

10 (6.0)

1 (0.6)

0.011

Fluoroquinolones, n (%)

101 (60.1)

113 (67.3)

0.212

Polymyxin B, n (%)

8 (4.8)

1 (0.6)

0.037

Linezolid, n (%)

13 (7.7)

4 (2.4)

0.044

Cephalosporin, n (%)

132 (78.6)

76 (45.2)

< 0.001

Tigecycline, n (%)

4 (2.4)

0 (0)

0.123

Duration of antibiotic therapy, days

7 (4 ~ 12)

11.3 ± 11.0

0.005

Anti-fungal therapy, n

137 (81.5)

N/A

N/A

Mould-active azole, n (%)

113 (67.3)

N/A

N/A

Amphotericin B, n (%)

43 (26.0)

N/A

N/A

Ganciclovir, n (%)

10 (6.0)

12 (7.1)

0.826

Ribavirin, n (%)

0 (0)

0 (0)

1.000

Amubarvimab, n (%)

8 (4.8)

25 (14.9)

0.003

Tocilizumab, n (%)

9 (5.4)

10 (6.0)

1.000

Antiviral therapy#, n (%)

88 (52.4)

74 (44.0)

0.156

Traditional Chinese Medicine, n (%)

15 (8.9)

14 (8.3)

1.000

Immunoglobulin, n (%)

70 (41.7)

46 (27.4)

0.008

Thymosin, n (%)

14 (8.3)

6 (3.6)

0.105

Glucocorticoid, n (%)

100 (59.5)

144 (85.7)

< 0.001

Duration of glucocorticoid therapy, days

7 (4 ~ 11)

8 (6 ~ 10)

0.188

Cumulative glucocorticoid dose*, mg

1577 (950 ~ 2358)

1400 (1100 ~ 2000)

0.478

Oxygen therapy, n (%)

156 (92.9)

99 (58.9)

< 0.001

High-flow oxygen therapy, n (%)

68 (40.5)

25 (14.9)

< 0.001

Non-invasive mechanical ventilation, n (%)

18 (10.7)

13 (7.7)

0.451

Invasive mechanical ventilation, n (%)

60 (35.7)

18 (10.7)

< 0.001

ECMO, n (%)

3 (1.8)

1 (0.6)

0.623

Invasive operation, n (%)

116 (69.1)

45 (26.8)

< 0.001

Indwelling urinary catheterization, n (%)

98 (58.3)

25 (14.9)

< 0.001

Central venous catheterization, n (%)

72 (42.9)

34 (20.2)

< 0.001

Puncture and drainage, n (%)

18 (10.7)

6 (3.6)

0.018

Tracheal intubation, n (%)

44 (26.2)

16 (9.5)

< 0.001

Tracheotomy, n (%)

12 (7.1)

6 (3.6)

0.225

Fiberoptic bronchoscopy, n (%)

23 (13.7)

14 (8.3)

0.163

CRRT, n (%)

11 (6.5)

4 (2.4)

0.110

Artificial liver treatment, n (%)

0 (0)

0 (0)

1.000