Differential distribution of linezolid in diseased and nondiseased bones in patients with spinal tuberculosis

BMC Infectious Diseases

Table 2 Linezolid concentrations in different sample types of spinal lesions

Patient No.	Specimen collection time (min)^c	Concentration (mg/L) of linezolid in:			Ratio^a
Patient No.	Specimen collection time (min)^c	Plasma	Nondiseased bone	Diseased bone	Nondiseased bone / plasma	Diseased bone / plasma	Diseased bone / nondiseased bone
1	139	2.16	0.96	1.63	0.44	0.75	1.70
2	150	9.45	4.05	5.39	0.43	0.57	1.33
3	180	3.44	1.01	2.13	0.29	0.62	2.11
4	220	3.29	0.65	1.87	0.20	0.57	2.88
5	140	12.03	1.96	3.50	0.16	0.29	1.79
6	105	9.05	0.63	3.22	0.07	0.36	5.11
7	200	8.231	2.025	2.030	0.246	0.247	1.002
Median	150	8.23	1.01	2.13	—^b	—^b	—^b
Mean	—^b	—^b	—^b	—^b	0.26	0.49	2.27
SD	—^b	—^b	—^b	—^b	0.14	0.19	1.39

^aRatio of linezolid concentrations in the two samples
^bNo data
^cTime from administration of preoperative dose of linezolid in the morning to sample collection during the operation

ISSN: 1471-2334