Multiple cytokine analysis based on QuantiFERON-TB gold plus in different tuberculosis infection status: an exploratory study

Table 3 AUCs of cytokines in each antigen tube for diagnosing TB infection

Parameter	TNF-α	IL-6	IP-10	MCP-1	IFN-γ	IL-1Ra	IL-2	CXCL-1
TB1-Nil
AUC (95%CI)	0.931 (0.852-1.000)	0.969 (0.929-1.000)	0.987 (0.963-1.000)	0.853 (0.751–0.956)	0.956 (0.894-1.000)	0.998 (0.991-1.000)	0.889 (0.801–0.977)	0.929 (0.834-1.000)
p	< 0.001	< 0.001	< 0.001	0.001	< 0.001	< 0.001	< 0.001	< 0.001
TB2-Nil
AUC (95%CI)	0.929 (0.852-1.000)	0.958 (0.906-1.000)	0.996 (0.984-1.000)	0.889 (0.798–0.980)	0.956 (0.875-1.000)	0.998 (0.991-1.000)	0.870 (0.775–0.965)	0.969 (0.923-1.000)
p	< 0.001	< 0.001	< 0.001	0.002	< 0.001	< 0.001	< 0.001	< 0.001
TB2-TB1
AUC (95%CI)	0.533 (0. 379-0. 688)	0. 559 (0.399–0.719)	0.662 (0.517–0.808)	0.611 (0.449–0.773)	0.633 (0.485–0.781)	0.660 (0.517–0.803)	0.572 (0.430–0.715)	0.497 (0.342–0.651)
p	0.743	0.563	0.111	0.275	0.190	0.116	0.478	0.974

ISSN: 1471-2334