Fig. 1

candidate miRNAs expression profile in the HPV-Positive Pap smear samples of patients with normal cytology and severe dysplasia. a and b expression analysis indicated a significant down-regulation of hsa-miR-194-5p (fold change: -2.628, P < 0.0001) and hsa-miR-195-5p (fold change: -1.584, P < 0.0001) in the HPV-Positive patients with severe dysplasia compared to normal cytology controls (median, mean, and standard deviation values displayed above each box plot). c HPV-positive individuals with severe dysplasia and normal cytology were distinguished using unsupervised hierarchical cluster analysis employing differentially expressed miRNAs. Red indicates miRNAs with relatively high expression, while miRNAs with low relative expression are shown in green on the heatmap (Euclidian distance, complete linkage). Heatmapper (http://www.heatmapper.ca) was used to make the heatmap