Characteristic | Total hospitalizations | p-value | SARS-CoV2 PCR Positive | p-value | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Wave 01 (%) | 4th (alpha) wave N (%) | 5th (delta) wave N (%) | 6th (omicron) wave N (%) | Wave 0 N (%) | 4th (alpha) wave N (%) | 5th (delta) wave N (%) | 6th (omicron) wave N (%) | |||
Overall | 3417 (25.5) | 2519 (18.9) | 5231 (39.3) | 2143 (16.1) | – | 644 (10) | 1402 (21.7) | 3573 (55.3) | 835 (12.9) | – |
Median age, yrs., (IQR) | 56 (39) | 56 (31) | 52 (28) | 62 (38) | < 0.001 | 55 (27) | 53 (24) | 52 (23) | 65 (34) | < 0.001 |
Mean ± SD, age, yrs | 49.66 ± 27.4 | 53.6 ± 21.82 | 49.5 ± 21.7 | 54.3 ± 27.5 | < 0.001 | 54.7 ± 19.3 | 53.5 ± 16.9 | 51.1 ± 17.4 | 58.6 ± 25.1 | < 0.001 |
Age group, yrs. | ||||||||||
  < 18 (n = 1690; 12.8%) | 634 (18.8) | 185 (7.4) | 522 (10) | 349 (16.4) | < 0.001 | 23 (3.6) | 18 (1.3) | 121 (3.4) | 84 (10.1) | < 0.001 |
 18–49 (n = 3721; 28.1%) | 776 (23) | 781 (31) | 1803 (34.6) | 361 (16.9) | 216 (33.6) | 567 (40.4) | 1445(40.5) | 160 (19.2) | ||
 50–64 (n = 3443; 26%) | 737 (21.9) | 686 (27.3) | 1557 (29.9) | 463 (21.7) | 206 (32) | 444 (31.7) | 1215 (34) | 166 (19.9) | ||
 65-79 (n = 2908; 22%) | 770 (22.9) | 588 (23.4) | 977 (18.7) | 573 (26.9) | 125 (19.4) | 276 (19.7) | 649 (18) | 246 (29.5) | ||
  ≥ 80 (n = 1468; 11.1%) | 451 (13.4) | 276 (11) | 353 (6.8) | 388 (18.2) | 73 (11.4) | 97 (6.9) | 149 (4.2) | 177 (21.2) | ||
Sex | ||||||||||
 Men | 1754 (51.3) | 1188 (47.2) | 2392 (45.7) | 1005 (46.9) | < 0.001 | 309 (48) | 614 (43.8) | 1533(42.9) | 377 (45.1) | 0.097 |
 Women | 1663 (48.7) | 1331 (52.8) | 2839 (54.3) | 1138 (53.1) | 335 (52) | 788 (56.2) | 2040(57.1) | 458 (54.9) | ||
Underlying diseases | ||||||||||
 CVD2 | 824 (24.1) | 652 (25.9) | 857 (16.4) | 635 (29.6) | < 0.001 | 158 (24.5) | 298 (21.3) | 484 (13.5) | 243 (29.1) | < 0.001 |
 Diabetics | 592 (17.3) | 433 (17.2) | 751 (14.4) | 397 (18.5) | < 0.001 | 116 (18) | 236 (16.8) | 520 (14.6) | 173 (20.7) | < 0.001 |
 KD3 | 137 (4) | 72 (2.9) | 103 (2) | 80 (3.7) | < 0.001 | 17 (2.6) | 33 (2.4) | 53 (1.5) | 34 (4.1) | < 0.001 |
 Hypertension | 444 (13) | 195 (7.7) | 372 (7.1) | 239 (11.2) | < 0.001 | 102 (15.8) | 101 (7.2) | 232 (6.5) | 92 (11) | < 0.001 |
 Malignancies | 243 (7.1) | 123 (4.9) | 160 (3.1) | 122 (5.7) | < 0.001 | 18 (2.8) | 29 (2.1) | 47 (1.3) | 40 (4.8) | < 0.001 |
 RD4 | 136 (4) | 82 (3.3) | 100 (1.9) | 73 (3.4) | < 0.001 | 15 (2.3) | 49 (3.5) | 54 (1.5) | 29 (3.5) | < 0.001 |
 GID5 | 34 (1) | 24 (0.95) | 31 (0.62) | 12 (0.54) | 0.061 | 5 (0.8) | 13 (0.9) | 11 (0.33) | 8 (0.9) | 0.005 |
 BND6 | 230 (6.7) | 132 (5.2) | 119 (3.4) | 160 (7.5) | < 0.001 | 35 (5.4) | 48 (3.4) | 84 (2.4) | 75 (9) | < 0.001 |
 BD7 | 23 (0.7) | 18 (0.7) | 14 (0.3) | 13 (0.6) | 0.016 | 2 (0.3) | 10 (0.7) | 9 (0.3) | 3 (0.4) | 0.118 |
 Pregnancy | 57 (1.7) | 19 (0.8) | 73 (1.4) | 30 (1.4) | 0.024 | 25 (3) | 8 (0.6) | 54 (1.5) | 25 (3) | 0.001 |
 Others8 | 25 (0.7) | 31 (1.2) | 29 (0.6) | 21 (1) | 0.012 | 3 (0.5) | 19 (1.4) | 12 (0.4) | 11 (1.3) | < 0.001 |
Comorbidities | ||||||||||
 No Comorbidities | 1570 (45.9) | 1219 (48.4) | 3346 (64) | 967 (45.1) | < 0.001 | 307 (47.7) | 767 (57.7) | 2458(68.8) | 344 (41.2) | < 0.001 |
 One | 1187 (34.7) | 917 (36.4) | 1258 (24) | 725 (33.8) | 222 (34.5) | 455 (32.5) | 749 (21) | 301 (36) | ||
  > = Two | 660 (19.3) | 383 (15.2) | 627 (12) | 451 (21) | 115 (17.9) | 180 (12.8) | 366 (10.2) | 190 (22.8) | ||
Hospitalization outcome | ||||||||||
 Length of stay, days, median (IQR) | 5 (4) | 5 (4) | 5 (3) | 5 (5) | < 0.001 | 5 (3) | 5 (3) | 5 (3) | 5 (4) | 0.066 |
 Length of stay, days, Mean ± SD | 7.6 ± 9.0 | 7.5 ± 11.3 | 7.1 ± 8.6 | 6.6 ± 6.0 | < 0.001 | 7.03 ± 10.9 | 6.6 ± 9.4 | 6.7 ± 7.5 | 6.3 ± 5.7 | 0.744 |
 ICU admission | 139 (4.1) | 97 (3.9) | 176 (3.4) | 75 (3.5) | 0.344 | 49 (7.6) | 62 (4.4) | 138 (3.9) | 42 (5) | < 0.001 |
 In-hospital death | 72 (2.1) | 167 (6.6) | 139 (2.7) | 43 (2) | < 0.001 | 17 (2.6) | 95 (6.8) | 96 (2.7) | 29 (3.5) | < 0.001 |